Butterfield D A
CRC Crit Rev Clin Neurobiol. 1986;2(2):169-240.
The molecular basis of many degenerative neurological diseases remains unknown. Biochemical, morphological, and genetic studies of several tissue types have provided some clues of the pathogenesis and etiology of such disorders; however, it has been spectroscopic investigations that have in several instances provided unifying bases for understanding the molecular defects involved. In particular, electron spin resonance, nuclear magnetic resonance, fluorescence, and Raman spectroscopic studies of cell membranes have provided needed insight into degenerative neurological disorders. This article will provide a brief background to each of the spectroscopic techniques listed above, will summarize our current understanding of cell membrane with special emphasis on the erythrocyte, and finally will give a critical evaluation of the literature of spectroscopic methods in degenerative neurological diseases.
许多退行性神经疾病的分子基础仍然未知。对多种组织类型进行的生化、形态学和遗传学研究为这些疾病的发病机制和病因提供了一些线索；然而，在若干情况下，正是光谱学研究为理解其中涉及的分子缺陷提供了统一的基础。特别是，对细胞膜进行的电子自旋共振、核磁共振、荧光和拉曼光谱研究为退行性神经疾病提供了必要的见解。本文将简要介绍上述每种光谱技术的背景知识，总结我们目前对细胞膜的理解，特别强调红细胞，最后对退行性神经疾病光谱学方法的文献进行批判性评价。
