EPIUnit - Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal; ITR- Laboratório para a Investigação Integrativa e Translacional, Porto, Portugal.
EPIUnit - Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal; ITR- Laboratório para a Investigação Integrativa e Translacional, Porto, Portugal.
Child Abuse Negl. 2022 Jun;128:105620. doi: 10.1016/j.chiabu.2022.105620. Epub 2022 Mar 30.
Youth and young adults with pain conditions report having a history of adverse childhood experiences (ACEs) more frequently than their healthy peers. The relationship between ACEs and pain before adolescence in population-based settings is not extensively researched.
To examine the association between the history of ACEs and bodily pain at 10 years of age.
Cross-sectional analysis of 4738 participants of Generation XXI population-based birth cohort, recruited in 2005-06 in Porto, Portugal.
Study includes self-reported data on ACEs exposures and bodily pain (pain presence, sites, and intensity a week prior to the interview). Adjusted odds ratios (AOR) and 95% confidence intervals (CI) were obtained from binary and multinomial logistic regression analyses to estimate the likelihood of various pain features according to the extent of exposure to ACEs (i.e., 0 ACEs, 1-3 ACEs, 4-5 ACEs, and ≥ 6 ACEs).
Prevalence of pain, multisite, and high-intensity pain a week prior to the interview increased with increasing exposure to ACEs. After controlling for sociodemographic characteristics, children who had experienced ≥6 ACEs were more likely to report pain [AOR 3.18 (95% CI 2.19, 4.74)], multisite pain [AOR 2.45 (95% CI 1.37, 4.40)], and high-intensity pain [AOR 4.27 (95% CI 2.56, 7.12)] compared with children with no ACEs.
A dose-response association was observed between the cumulative number of ACEs and reports of pain in 10-year-old children, suggesting that embodiment of ACEs starts as early as childhood and that pain related to ACEs begins earlier than previously reported.
患有疼痛病症的青年和年轻人比他们健康的同龄人更频繁地报告有不良童年经历（ACE）史。在基于人群的环境中，青春期前 ACE 与疼痛之间的关系尚未得到广泛研究。
研究 ACE 史与 10 岁时躯体疼痛之间的关联。
横断面分析了 2005-06 年在葡萄牙波尔图招募的 21 世纪人口出生队列的 4738 名参与者。
研究包括 ACE 暴露和躯体疼痛的自我报告数据（疼痛存在、部位和访谈前一周的疼痛强度）。采用二元和多项逻辑回归分析获得调整后的优势比（AOR）和 95%置信区间（CI），以根据 ACE 暴露程度（即 0 ACE、1-3 ACE、4-5 ACE 和 ≥6 ACE）估计各种疼痛特征的可能性。
访谈前一周疼痛、多部位和高强度疼痛的患病率随着 ACE 暴露程度的增加而增加。在控制社会人口统计学特征后，经历 ≥6 ACE 的儿童更有可能报告疼痛 [AOR 3.18（95% CI 2.19，4.74）]、多部位疼痛 [AOR 2.45（95% CI 1.37，4.40）] 和高强度疼痛 [AOR 4.27（95% CI 2.56，7.12）]。
在 10 岁儿童中，ACE 累积数量与疼痛报告之间观察到剂量反应关联，这表明 ACE 的体现早在儿童时期就开始了，与 ACE 相关的疼痛比以前报告的更早开始。
Zotero 插件