循环中MAIT细胞增加在肺癌中的作用：一项初步研究。
Participation of Increased Circulating MAIT Cells in Lung Cancer: a Pilot Study.
作者信息
Zhang Qian, Li Pengli, Zhou Wenqin, Fang Shu, Wang Jiong
机构信息
Department of Geriatric Respiratory and Critical Care, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
School of Biomedical Engineering, Anhui Medical University, Hefei, Anhui, China.
出版信息
J Cancer. 2022 Mar 6;13(5):1623-1629. doi: 10.7150/jca.69415. eCollection 2022.
Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T cells that regulate the immune response via rapidly releasing inflammatory factors, including during progression of some tumors. However, the immunological role of MAIT cells is still unclear in lung cancer. We measured percentage, partial function, and clinical correlation of circulating MAIT cells from lung cancer patients through flow cytometry. Lung cancer patients displayed a high concentration of CD4, CD8, and activated CD38CD8MAIT cells, and a decrease of PD1 double negative (DN) MAIT cells in peripheral blood. Meanwhile, increased levels of interferon-γ, interleukin (IL)-6, and 8 were examined in the serum of lung cancer patients. Importantly, we discovered a statistically positive association between accumulation of CD38CD8MAIT cells and reduced progression-free survival of lung cancer patients. While preliminary, the altering frequency of MAIT cells might be involved in dysfunctional immune response in lung cancer.
黏膜相关恒定T（MAIT）细胞是一类固有样T细胞亚群，可通过快速释放炎性因子来调节免疫反应，在某些肿瘤进展过程中亦是如此。然而，MAIT细胞在肺癌中的免疫作用仍不清楚。我们通过流式细胞术检测了肺癌患者循环MAIT细胞的百分比、部分功能及临床相关性。肺癌患者外周血中CD4、CD8及活化的CD38CD8 MAIT细胞浓度较高，而PD1双阴性（DN）MAIT细胞减少。同时，在肺癌患者血清中检测到干扰素-γ、白细胞介素（IL）-6和8水平升高。重要的是，我们发现CD38CD8 MAIT细胞的积累与肺癌患者无进展生存期缩短之间存在统计学上的正相关。虽然尚属初步研究，但MAIT细胞频率的改变可能参与了肺癌中功能失调的免疫反应。
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