Suppr超能文献

迷你综述:阿尔茨海默病的潜在治疗靶点

Mini review: Prospective therapeutic targets of Alzheimer's disease.

作者信息

Mangal Ruchi, Ding Yuchuan

机构信息

Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA.

出版信息

Brain Circ. 2022 Mar 21;8(1):1-5. doi: 10.4103/bc.bc_20_21. eCollection 2022 Jan-Mar.

Abstract

Alzheimer's disease is a neurological condition that causes the disruption of neuronal connections in the human brain. It is progressive and targets about 10% of the United States population over the age of 65.3 to date, there is no cure to the disease. Physicians can treat symptoms but lack the ability to stop the progression of the disease. However, promising research has come to the surface in recent years. A collection of these therapeutic targets, which have yielded positive results in mice models, are presented in this article. They include targets such as meningeal lymphatics, mitochondrial homeostasis, genomic instability, calcium homeostasis, and cold-shock proteins such as RNA-binding motif protein 3 and reticulon-3, high-density lipoprotein, and antibodies.

摘要

阿尔茨海默病是一种导致人类大脑神经元连接中断的神经疾病。它是渐进性的,影响着美国65岁以上约10%的人口。迄今为止,这种疾病无法治愈。医生可以治疗症状,但无法阻止疾病的进展。然而,近年来出现了一些有前景的研究。本文介绍了一系列在小鼠模型中产生了积极结果的治疗靶点。它们包括诸如脑膜淋巴管、线粒体稳态、基因组不稳定、钙稳态等靶点,以及诸如RNA结合基序蛋白3和网织蛋白-3等冷休克蛋白、高密度脂蛋白和抗体。

相似文献

1
Mini review: Prospective therapeutic targets of Alzheimer's disease.
Brain Circ. 2022 Mar 21;8(1):1-5. doi: 10.4103/bc.bc_20_21. eCollection 2022 Jan-Mar.
2
Donanemab in Early Alzheimer's Disease.
N Engl J Med. 2021 May 6;384(18):1691-1704. doi: 10.1056/NEJMoa2100708. Epub 2021 Mar 13.
6
Nimodipine for primary degenerative, mixed and vascular dementia.
Cochrane Database Syst Rev. 2001(1):CD000147. doi: 10.1002/14651858.CD000147.
7
Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease.
J Neurovirol. 2019 Oct;25(5):702-709. doi: 10.1007/s13365-018-0695-4. Epub 2019 Jan 4.
8
Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels.
Front Immunol. 2020 Jan 14;10:3043. doi: 10.3389/fimmu.2019.03043. eCollection 2019.
9
Connections Between Amyloid Beta and the Meningeal Lymphatics As a Possible Route for Clearance and Therapeutics.
Lymphat Res Biol. 2020 Feb;18(1):2-6. doi: 10.1089/lrb.2018.0079. Epub 2019 Aug 21.

引用本文的文献

1
From genes to drugs: targeting Alzheimer's with circadian insights.
Front Aging Neurosci. 2025 Mar 26;17:1527636. doi: 10.3389/fnagi.2025.1527636. eCollection 2025.
3
Decoding Alzheimer's Disease With Depression: Molecular Insights and Therapeutic Target.
J Cell Mol Med. 2025 Mar;29(5):e70454. doi: 10.1111/jcmm.70454.
6
Causal relationships between dyslexia and the risk of eight dementias.
Transl Psychiatry. 2024 Sep 12;14(1):371. doi: 10.1038/s41398-024-03082-9.
8
Greater Omentum: Multifaceted Interactions in Neurological Recovery and Disease Progression.
Aging Dis. 2024 Feb 19;15(6):2381-2394. doi: 10.14336/AD.2024.0213.
9
From rodents to humans: Rodent behavioral paradigms for social behavioral disorders.
Brain Circ. 2023 Sep 27;9(3):154-161. doi: 10.4103/bc.bc_48_23. eCollection 2023 Jul-Sep.

本文引用的文献

1
Donanemab in Early Alzheimer's Disease.
N Engl J Med. 2021 May 6;384(18):1691-1704. doi: 10.1056/NEJMoa2100708. Epub 2021 Mar 13.
3
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.
Nat Commun. 2020 May 18;11(1):2484. doi: 10.1038/s41467-020-16361-y.
4
Amyloid pathology-produced unexpected modifications of calcium homeostasis in hippocampal subicular dendrites.
Alzheimers Dement. 2020 Feb;16(2):251-261. doi: 10.1016/j.jalz.2019.07.017. Epub 2020 Jan 6.
5
HDL from an Alzheimer's disease perspective.
Curr Opin Lipidol. 2019 Jun;30(3):224-234. doi: 10.1097/MOL.0000000000000604.
6
Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease.
Nature. 2018 Aug;560(7717):185-191. doi: 10.1038/s41586-018-0368-8. Epub 2018 Jul 25.
7
RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3.
Curr Biol. 2017 Mar 6;27(5):638-650. doi: 10.1016/j.cub.2017.01.047. Epub 2017 Feb 23.
8
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.
Nature. 2015 Feb 12;518(7538):236-9. doi: 10.1038/nature14142. Epub 2015 Jan 14.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验