Mangal Ruchi, Ding Yuchuan
Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA.
Brain Circ. 2022 Mar 21;8(1):1-5. doi: 10.4103/bc.bc_20_21. eCollection 2022 Jan-Mar.
Alzheimer's disease is a neurological condition that causes the disruption of neuronal connections in the human brain. It is progressive and targets about 10% of the United States population over the age of 65.3 to date, there is no cure to the disease. Physicians can treat symptoms but lack the ability to stop the progression of the disease. However, promising research has come to the surface in recent years. A collection of these therapeutic targets, which have yielded positive results in mice models, are presented in this article. They include targets such as meningeal lymphatics, mitochondrial homeostasis, genomic instability, calcium homeostasis, and cold-shock proteins such as RNA-binding motif protein 3 and reticulon-3, high-density lipoprotein, and antibodies.
阿尔茨海默病是一种导致人类大脑神经元连接中断的神经疾病。它是渐进性的,影响着美国65岁以上约10%的人口。迄今为止,这种疾病无法治愈。医生可以治疗症状,但无法阻止疾病的进展。然而,近年来出现了一些有前景的研究。本文介绍了一系列在小鼠模型中产生了积极结果的治疗靶点。它们包括诸如脑膜淋巴管、线粒体稳态、基因组不稳定、钙稳态等靶点,以及诸如RNA结合基序蛋白3和网织蛋白-3等冷休克蛋白、高密度脂蛋白和抗体。