一种针对阿尔茨海默病患者大脑中淀粉样蛋白的单克隆抗体。
A monoclonal antibody to amyloid in the brains of patients with Alzheimer's disease.
作者信息
Ishii T, Sato M, Haga S, Shinoda T, Kato K, Saito T
出版信息
Neuropathol Appl Neurobiol. 1986 Sep-Oct;12(5):441-5. doi: 10.1111/j.1365-2990.1986.tb00052.x.
A monoclonal antibody that reacts with the amyloid in senile plaques in the brains of patients with Alzheimer's disease, was produced. The antigen was the crude amyloid protein (DAM, Pras et al. 1968) from the spleen of a patient with primary amyloidosis. The antibody crossreacts with DAM, but does not stain the amyloid of primary amyloidosis in tissue sections. The presence of a common antigenic site or sites in both the amyloid of senile plaques and amyloid of primary amyloidosis which react with this antibody is postulated.
制备了一种单克隆抗体，它能与阿尔茨海默病患者大脑老年斑中的淀粉样蛋白发生反应。抗原是来自一名原发性淀粉样变性患者脾脏的粗淀粉样蛋白（DAM，普拉斯等人，1968年）。该抗体与DAM发生交叉反应，但在组织切片中不染色原发性淀粉样变性的淀粉样蛋白。推测老年斑淀粉样蛋白和原发性淀粉样变性淀粉样蛋白中存在一个或多个与该抗体反应的共同抗原位点。
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