CRISIS 呼吸机：应对大规模呼吸道传染病呼吸机激增的 3D 打印方案。
CRISIS ventilator: A 3D printed option for ventilator surge in mass respiratory pandemics.
机构信息
Oregon Health and Science University, Division of General Surgery, USA.
Oregon Health and Science University, Division of Trauma, Acute Care, Critical Care, USA.
出版信息
Am J Surg. 2022 Jul;224(1 Pt B):569-575. doi: 10.1016/j.amjsurg.2022.02.064. Epub 2022 Mar 11.
BACKGROUND
The COVID-19 pandemic revealed flaws in the stockpiling and distribution of ventilators. In this study, we assessed the durability, sterilizability, and performance of a 3D-printed ventilator.
METHODS
SLS-printed devices were dropped from 1.83 m and autoclaved before evaluation on a COVID-19 simulated patient. The respiratory performance of an extrusion-printed device was studied using a variable compliance model. Ranges of sustainable respiratory rates were evaluated as a function of tidal volume.
RESULTS
Autoclaving and dropping the device did not negatively impact minute ventilation or PIP for sustained ventilation. Equivalence was significant across all measures except for comparing the autoclaved and dropped with p = 0.06. Extrusion produced ventilators achieved minute ventilation ranging from 4.1 to 12.2 L/min for all simulated compliances; there was an inverse correlation between tidal volume and respiratory rate.
CONCLUSION
The CRISIS ventilator is a durable, sterilizable, and reusable 3D-printed ventilator using off-the-shelf materials which could be employed variety of adult lung diseases. Further in-vivo testing is needed.
背景
COVID-19 大流行暴露了呼吸机储备和分配方面的缺陷。在这项研究中，我们评估了一款 3D 打印呼吸机的耐用性、可消毒性和性能。
方法
将 SLS 打印设备从 1.83 米高处掉落并进行高压灭菌，然后在模拟 COVID-19 患者的情况下进行评估。使用可变顺应性模型研究挤出打印设备的呼吸性能。作为潮气量的函数，评估可持续呼吸频率的范围。
结果
高压灭菌和设备掉落并未对持续通气的分钟通气量或 PIP 产生负面影响。除了比较高压灭菌和掉落的情况，p=0.06，所有测量指标的等效性均具有统计学意义。挤出式呼吸机在所有模拟顺应性下的分钟通气量范围为 4.1 至 12.2 L/min；潮气量与呼吸频率呈反比关系。
结论
CRISIS 呼吸机是一种耐用、可消毒、可重复使用的 3D 打印呼吸机，使用现成的材料，可用于多种成人肺部疾病。需要进一步的体内测试。
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