Ding Rui, Xiao Yi, Mo Miao, Zheng Ying, Jiang Yi-Zhou, Shao Zhi-Ming
Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Cancer Biol Med. 2022 Apr 5;19(4):450-67. doi: 10.20892/j.issn.2095-3941.2021.0676.
Breast cancer is the most common malignant tumor in Chinese women, and its incidence is increasing. Regular screening is an effective method for early tumor detection and improving patient prognosis. In this review, we analyze the epidemiological changes and risk factors associated with breast cancer in China and describe the establishment of a screening strategy suitable for Chinese women. Chinese patients with breast cancer tend to be younger than Western patients and to have denser breasts. Therefore, the age of initial screening in Chinese women should be earlier, and the importance of screening with a combination of ultrasound and mammography is stressed. Moreover, Chinese patients with breast cancers have several ancestry-specific genetic features, and aiding in the determination of genetic screening strategies for identifying high-risk populations. On the basis of current studies, we summarize the development of risk-stratified breast cancer screening guidelines for Chinese women and describe the significant improvement in the prognosis of patients with breast cancer in China.
乳腺癌是中国女性中最常见的恶性肿瘤,且其发病率呈上升趋势。定期筛查是早期发现肿瘤并改善患者预后的有效方法。在本综述中,我们分析了中国乳腺癌的流行病学变化及相关危险因素,并描述了适合中国女性的筛查策略的建立。中国乳腺癌患者往往比西方患者更年轻,且乳房密度更高。因此,中国女性初次筛查的年龄应更早,强调了超声和乳腺X线摄影联合筛查的重要性。此外,中国乳腺癌患者具有一些特定祖先的遗传特征,有助于确定识别高危人群的基因筛查策略。基于当前研究,我们总结了中国女性风险分层乳腺癌筛查指南的发展情况,并描述了中国乳腺癌患者预后的显著改善。