From the Faculty of Nursing, Mansoura University, Mansoura, Egypt.
From the Dasman Diabetes Institute, Kuwait City, Kuwait.
Exp Clin Transplant. 2022 Mar;20(Suppl 1):46-54. doi: 10.6002/ect.MESOT2021.O19.
Diabetes knowledge among kidney transplant recipients with posttransplant diabetes has not been exhaustively assessed. Here, we evaluated the effects of structured diabetes education on development of diabetic micro- and macroangiopathies in kidney transplant patients with posttransplant diabetes.
This prospective randomized controlled study categorized 210 renal transplant patients with posttransplant diabetes mellitus into 2:1 groups according to type of diabetes education. Group 1 (n = 140) received structured education, and group 2 (n = 70) received conventional education. Patient data were collected through patient identification and metabolic control parameter forms.
Most patients in groups 1 and 2, respectively, were Kuwaiti (60.7% vs 58.6%), men (57.9% vs 68.6%), and had high school-level education (43.6% vs 48.6%). Chronic glomerulonephritis was the original disease in 36.4% versus 35.4% of patients. Most patients (72.8% vs 78.6% in group 1 vs 2) received pretransplant hemodialysis. At study start, the rate of patients with diabetic neuropathy was comparable between groups (32.4% vs 27.9%). Moreover, after completion of 24 months of education, neurological evaluation by electromyograph and nerve conduction studies did not show any significant differences between the groups (P > .05). Similarly, the number of patients with fundus imaging showing retinopathy was comparable between groups at start and end of study (P > .05). Although macroangiopathic events were higher in group 1, this finding was not significant (P > .05). However, although the percentage of patients with nephropathy was comparable in both groups at start of study, the percentage decreased significantly in group 1 at 24 months after completion of education compared with group 2 and baseline value (P = .016).
Structured diabetes education was associated with reduced diabetic nephropathy but had no significant effects on other micro- or macroangiopathies. However, we recommend education for all kidney transplant recipients with diabetes.
接受肾移植的糖尿病患者的糖尿病知识尚未得到充分评估。在此,我们评估了结构化糖尿病教育对肾移植后并发糖尿病患者发生糖尿病微血管和大血管并发症的影响。
这项前瞻性随机对照研究根据糖尿病教育的类型,将 210 例肾移植后并发糖尿病的患者分为 2:1 组。第 1 组(n = 140)接受结构化教育,第 2 组(n = 70)接受常规教育。通过患者识别和代谢控制参数表收集患者数据。
第 1 组和第 2 组患者分别有 60.7%(60.7% vs 58.6%)和 57.9%(57.9% vs 68.6%)为科威特人,分别有 43.6%(43.6% vs 48.6%)和 48.6%(43.6% vs 48.6%)接受过高中教育。慢性肾小球肾炎是 36.4%(36.4% vs 35.4%)与 35.4%(36.4% vs 35.4%)患者的原发病。大多数患者(72.8% vs 78.6%,第 1 组 vs 第 2 组)接受了移植前血液透析。在研究开始时,两组患者的糖尿病神经病变发生率相当(32.4% vs 27.9%)。此外,经过 24 个月的教育后,肌电图和神经传导研究的神经学评估结果在两组之间没有显示出任何显著差异(P>0.05)。同样,在研究开始和结束时,眼底成像显示视网膜病变的患者数量在两组之间也相当(P>0.05)。尽管第 1 组的大血管事件发生率较高,但这一发现没有统计学意义(P>0.05)。然而,尽管两组患者在研究开始时的肾病发生率相当,但与第 2 组和基线值相比,第 1 组在教育结束后 24 个月时的百分比显著下降(P = 0.016)。
结构化糖尿病教育与减少糖尿病肾病有关,但对其他微血管或大血管病变没有显著影响。然而,我们建议对所有患有糖尿病的肾移植受者进行教育。