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螨性变应性鼻炎的精准医学

Precision Medicine in Mite Allergic Rhinitis.

作者信息

González-Pérez Ruperto, El-Qutob David, Letrán Antonio, Matheu Víctor

机构信息

Allergy Department, Complejo Hospital Universitario de Canarias, San Cristóbal de La Laguna, Spain.

Allergy Unit, University Hospital of La Plana, Villarreal, Spain.

出版信息

Front Allergy. 2021 Sep 27;2:724727. doi: 10.3389/falgy.2021.724727. eCollection 2021.

Abstract

It is well-known that a correct diagnosis is necessary for effective treatment. In the case of allergic rhinitis due to mites, imprecise diagnosis with effective but improvable methods means that in many cases an optimal result is not reached in patients. The diagnosis of allergic rhinitis due to mite sensitization have to require more homogeneously reproducible diagnostic tests that try to encompass many more of the protein antigens contained in them. With the few proteins that the problem has usually focused on, there is no they would cover many of the clinically relevant allergens in a large proportion of patients. In this mini-review we try to highlight the importance of having good allergenic sources and briefly gather information on various allergenic proteins included in mites that could be clinically relevant. All this to try to get closer to a more accurate diagnosis. We are also talking about two diagnostic tools that are clearly out of use and that should be promoted in the consultations to obtain an even greater and better outcome in patients.

摘要

众所周知,正确的诊断对于有效治疗至关重要。对于因螨虫引起的过敏性鼻炎,采用有效但仍可改进的方法进行不精确诊断意味着在许多情况下,患者无法获得最佳治疗效果。因螨虫致敏导致的过敏性鼻炎诊断需要更具同质性且可重复的诊断测试,这些测试应涵盖螨虫中包含的更多蛋白质抗原。由于以往通常关注的蛋白质种类较少,它们无法涵盖大部分患者中许多临床相关的过敏原。在本综述中,我们试图强调拥有优质过敏原来源的重要性,并简要收集有关螨虫中可能具有临床相关性的各种过敏原蛋白的信息。所有这些都是为了更接近准确诊断。我们还讨论了两种明显未得到充分利用的诊断工具,应在会诊中推广使用,以便在患者中取得更好的治疗效果。

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