Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, No. 11 Datun Road, Beijing, 100101, China.
Centre for Environment and Population Health, School of Medicine, Griffith University, 170 Kessels Road, Nathan, QLD, 4111, Australia.
Environ Sci Pollut Res Int. 2022 Aug;29(39):59547-59560. doi: 10.1007/s11356-022-19927-z. Epub 2022 Apr 7.
Pymetrozine is one of the most commonly used insecticides in China. This study was conducted to analyse Pymetrozine's potential exposures through various environmental routes beyond the treatment areas. The aim was to estimate the potential health risk for communities due to non-dietary exposures to Pymetrozine in soil and paddy water. Data on registration of pesticides in China, government reports, questionnaires, interviews and literature reviews as well as toxicological health investigations were evaluated to determine the hazard and dose-response characteristics of Pymetrozine. These were based on the US EPA exposure and human health risk assessment methods and exposure data from soil and paddy water samples collected between 10 and 20 m around the resident's location. The exposure doses from dermal contact through soil and paddy water were estimated. The potential cancer risk from the following exposure routes was evaluated: ingestion through soil; dermal contact exposure through soil; dermal contact exposure through paddy water. The potential total cancer risk for residents was estimated to be less than 1 × 10. These were relatively low and within the acceptable risk levels. The potential hazard quotient (HQ) from acute and lifetime exposure by dermal contact through paddy water and soil and acute and lifetime exposure by soil ingestion for residents was less than 1, indicating an acceptable risk level. This study suggested that there were negligible cancer risk and non-cancer risks based on ingestion and dermal contact routes of exposure to residents.
吡丙醚是中国最常用的杀虫剂之一。本研究旨在分析吡丙醚通过治疗区以外的各种环境途径的潜在暴露情况。目的是评估由于土壤和稻田水中非饮食暴露于吡丙醚而对社区造成的潜在健康风险。对中国农药登记、政府报告、问卷调查、访谈和文献综述以及毒理学健康调查的数据进行了评估，以确定吡丙醚的危害和剂量-反应特征。这些都是基于美国环保署的暴露和人类健康风险评估方法以及在居民所在地周围 10 至 20 米范围内收集的土壤和稻田水样中的暴露数据。评估了通过土壤和稻田水进行皮肤接触的暴露剂量。评估了以下暴露途径的潜在癌症风险：通过土壤摄入；通过土壤进行皮肤接触暴露；通过稻田水进行皮肤接触暴露。估计居民的潜在总癌症风险小于 1×10。这些风险相对较低，处于可接受的风险水平内。居民通过稻田水和土壤的皮肤接触急性和终生暴露以及通过土壤摄入的急性和终生暴露的潜在危害系数（HQ）均小于 1，表明风险处于可接受水平。本研究表明，基于居民对吡丙醚的摄入和皮肤接触暴露途径，其致癌风险和非致癌风险可忽略不计。
