先天性膈疝婴儿的急性肾损伤。
Acute kidney injury in infants with congenital diaphragmatic hernia.
机构信息
Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Neonatal Intensive Care Centre, King's College Hospital NHS Foundation Trust, London, UK.
出版信息
J Perinatol. 2022 Jul;42(7):925-929. doi: 10.1038/s41372-022-01378-6. Epub 2022 Apr 7.
OBJECTIVES
To assess the incidence of acute kidney injury (AKI) in infants with congenital diaphragmatic hernia (CDH), including those who had fetoscopic endoluminal tracheal occlusion (FETO), and the effect of AKI on mortality and length of stay.
STUDY DESIGN
Ten-year retrospective review of infants admitted with CDH to a tertiary perinatal centre.
RESULT
Ninety-four infants with median gestational age of 38 weeks were included. Fifty-nine (62.8%) infants had AKI. Compared to infants without AKI, infants with AKI, had a similar incidence of mortality (p = 0.989). In survivors, AKI was not independently associated with a longer adjusted median length of stay [23 versus 15 days (p = 0.194)]. FETO was associated with an increased risk of AKI (p = 0.005), but neither the mortality nor length of stay of FETO infants who had AKI was increased.
CONCLUSION
AKI was present in the majority of infants with CDH and most common in those who had undergone FETO.
目的
评估先天性膈疝（CDH）婴儿的急性肾损伤（AKI）发生率，包括接受经食管镜腔内气管阻塞术（FETO）的婴儿，并评估 AKI 对死亡率和住院时间的影响。
研究设计
对一家三级围产中心收治的 CDH 婴儿进行的 10 年回顾性研究。
结果
共纳入 94 例中位胎龄为 38 周的婴儿。59 例（62.8%）婴儿发生 AKI。与无 AKI 的婴儿相比，AKI 婴儿的死亡率相似（p=0.989）。在幸存者中，AKI 与调整后的中位住院时间延长无关[23 天与 15 天（p=0.194）]。FETO 与 AKI 风险增加相关（p=0.005），但 FETO 婴儿发生 AKI 并不增加死亡率或住院时间。
结论
CDH 婴儿中 AKI 较为常见，大多数接受 FETO 的婴儿发生 AKI。
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