Geriatrics and Extended Care Data and Analysis Center (GECDAC), Finger Lakes Healthcare System, Canandaigua, New York, USA.
Public Health Sciences, University of Rochester, Rochester, New York, USA.
J Am Geriatr Soc. 2022 Aug;70(8):2393-2403. doi: 10.1111/jgs.17785. Epub 2022 Apr 9.
Pain assessment and management of Veterans with Alzheimer's disease and Related Dementia (ADRD) living in Community Living Centers (CLCs) is challenging. Safe and effective use of opioids in the treatment of pain is of great concern to patients and providers promulgating national policies and guidelines.
This study examined long-stay CLC Veterans with ADRD identified in three regulatory periods (period 1: 10/2012-6/2013, n = 3347; period 2: 1/2014-11/2015, n = 4426; period 3: 1/2017-9/2018, n = 4444; Total N = 12,217).This population-based observational study used CLC Minimum Data Set (MDS) data in Fiscal Years (FYs) 2013-2018 and VA bar-code medication administration (BCMA) data. Opioid administration measures included: any opioids, long-term opioids, high-dose opioids, and co-administration with benzodiazepine. Measures were modeled using negative binomial regression with length of stay in CLC as offset adjusting for Veteran predisposing, enabling and need measures from the MDS.
Compared to period 1, any opioid administration was 26% lower in period 2, and 34% lower in period 3. Among Veterans who received any opioid medications over the three regulatory periods, high-dose and long-term opioid administration were more than 40% lower in periods 2 and 3 compared to period 1. Co-administration of opioid with benzodiazepine versus no opioid was 11% lower in period 2 and 34% lower in period 3 after adjusting for patient level covariates.
All patterns of opioid administration decreased over the four opioid regulations periods when guidelines were promulgated across the VA health system. Further research should clarify whether decreasing opioids among patients with ADRD impacted health outcomes.
在社区生活中心(CLC)中,对患有阿尔茨海默病和相关痴呆症(ADRD)的退伍军人进行疼痛评估和管理具有挑战性。安全有效地使用阿片类药物治疗疼痛是患者和制定国家政策和指南的医务人员非常关注的问题。
本研究调查了在三个监管期(第 1 期:2012 年 10 月至 2013 年 6 月,n=3347;第 2 期:2014 年 1 月至 2015 年 11 月,n=4426;第 3 期:2017 年 1 月至 2018 年 9 月,n=4444;总人数=12217)中确定的长期居住在 CLC 的 ADRD 退伍军人。这项基于人群的观察性研究使用了 CLC 最小数据集(MDS)数据(2013 年至 2018 财年)和 VA 条码药物管理(BCMA)数据。阿片类药物管理措施包括:任何阿片类药物、长期阿片类药物、高剂量阿片类药物以及与苯二氮䓬类药物联合使用。使用负二项回归模型对措施进行建模,以 CLC 中的住院时间为偏移量进行调整,以调整 MDS 中的退伍军人易感性、使能和需求措施。
与第 1 期相比,第 2 期任何阿片类药物的使用率降低了 26%,第 3 期降低了 34%。在三个监管期内接受任何阿片类药物治疗的退伍军人中,与第 1 期相比,第 2 期和第 3 期高剂量和长期阿片类药物的使用率分别降低了 40%以上。在调整患者水平协变量后,第 2 期和第 3 期阿片类药物与苯二氮䓬类药物联合使用的比例分别降低了 11%和 34%,而没有使用阿片类药物。
在 VA 卫生系统发布所有阿片类药物规定期间,所有阿片类药物管理模式均呈下降趋势。进一步的研究应该阐明在 ADRD 患者中减少阿片类药物是否会影响健康结果。