双相情感障碍与骨骼健康：一项病例对照研究。

Bipolar disorder and bone health: A case-control study.

机构信息

Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Geelong, Victoria, Australia; Barwon Health, Geelong, Victoria, Australia.

Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Geelong, Victoria, Australia.

出版信息

J Affect Disord. 2022 Jul 1;308:39-43. doi: 10.1016/j.jad.2022.04.016. Epub 2022 Apr 6.

DOI:10.1016/j.jad.2022.04.016

PMID:35398110

Abstract

BACKGROUND

Bipolar disorder (BD) is associated with significant psychological and physical comorbidity. Yet little is known about the bone health of individuals with BD. Thus, we aimed to investigate the association between BD and bone health in a population-based sample of women.

METHODS

Women with a history of BD (cases; n = 117) were recruited from public and private health care settings and controls, without BD, were drawn from the Geelong Osteoporosis Study (n = 909). BD was identified using a semi-structured clinical interview (SCID-I/NP). Bone mineral density (BMD) was measured at the spine, femoral neck and total body using dual energy x-ray absorptiometry, and bone quality by quantitative heel ultrasound and included the following parameters: Speed of Sound (SOS), Broadband Ultrasound Attenuation (BUA) and Stiffness Index (SI). Weight and height were measured and information on medication use and lifestyle was obtained.

RESULTS

Adjusted mean BMD among the cases was 4.3% lower at the hip and 1.6% lower at the total body compared to controls. Age was an effect modifier at the spine. Among women <50 years, mean spine BMD for cases was 3.5% lower than controls. No differences in spine BMD for those ≥50 years were detected. Cases also had a 1.0%, 3.2% and 7.8% lower adjusted mean SOS, BUA and SI compared to controls, respectively.

LIMITATIONS

Course, chronicity and recovery of BD were not explored in relation to bone health.

CONCLUSION

These data suggest BD is associated with low bone quantity and quality in women. Replication and research into underlying mechanisms is warranted.

摘要

背景

双相情感障碍（BD）与显著的心理和身体共病有关。然而，人们对 BD 患者的骨骼健康知之甚少。因此，我们旨在调查基于人群的女性样本中 BD 与骨骼健康之间的关联。

方法

从公共和私人医疗保健机构招募了有 BD 病史的女性（病例；n=117），并从基隆骨质疏松研究（n=909）中招募了无 BD 的对照。BD 通过半结构化临床访谈（SCID-I/NP）进行识别。使用双能 X 射线吸收法测量脊柱、股骨颈和全身的骨密度（BMD），并通过定量足跟超声测量骨质量，包括以下参数：声速（SOS）、宽带超声衰减（BUA）和刚度指数（SI）。测量体重和身高，并获取药物使用和生活方式信息。

结果

与对照组相比，病例组髋部的平均 BMD 低 4.3%，全身的平均 BMD 低 1.6%。年龄是脊柱的效应修饰剂。在<50 岁的女性中，病例组的脊柱 BMD 比对照组低 3.5%。对于≥50 岁的女性，未发现脊柱 BMD 存在差异。与对照组相比，病例组的调整平均 SOS、BUA 和 SI 分别低 1.0%、3.2%和 7.8%。