Faulstich M E
Int J Neurosci. 1986 Nov;30(4):249-54. doi: 10.3109/00207458608985675.
The Acquired Immune Deficiency Syndrome (AIDS) has been associated with a series of central nervous system (CNS) complications, including focal and nonfocal neurological indications. Overall, the most common form of CNS dysfunction is diffuse cerebral atrophy pathologically characterized by neuronal loss, glial nodules, and microfocal demyelination. Consequent neuropsychological deficits present an insidious course initially typified by poor memory and concentration, along with psychomotor retardation and blunted affect which resembles psychological depression. Gradually over several weeks to months, patients exhibit marked global cognitive impairment and can become severely disoriented and delusional. Clinical research relevant to these CNS complications and neuropsychological sequelae are reviewed.
获得性免疫缺陷综合征（艾滋病）与一系列中枢神经系统（CNS）并发症有关，包括局灶性和非局灶性神经学指征。总体而言，中枢神经系统功能障碍最常见的形式是弥漫性脑萎缩，其病理特征为神经元丧失、胶质结节和微灶性脱髓鞘。随之而来的神经心理缺陷呈现出隐匿的病程，最初表现为记忆力和注意力差，伴有精神运动迟缓以及类似于心理抑郁的情感迟钝。在数周或数月的时间里，患者会逐渐出现明显的全面认知障碍，并可能变得严重定向障碍和妄想。本文综述了与这些中枢神经系统并发症和神经心理后遗症相关的临床研究。
