Liu Yuanbin, Chen Mingkai
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, P. R. China.
Gastroenterol Rep (Oxf). 2022 Apr 7;10:goac011. doi: 10.1093/gastro/goac011. eCollection 2022.
Microscopic colitis (MC) is a chronic inflammatory disease of the large intestine and as a relatively late recognized condition, its relationship with other disorders of the gastrointestinal tract is gradually being understood and investigated. As a multifactorial disease, MC interacts with inflammatory bowel disease, celiac disease, and irritable bowel syndrome through genetic overlap, immunological factors, and gut microflora. The risk of colorectal cancer was significantly lower in MC, gastrointestinal infections increased the risk of developing MC, and there was an inverse association between infection and MC. A variety of associations are found between MC and other gastrointestinal disorders, where aspects such as genetic effects, resemblance of immunological profiles, and intestinal microecology are potential mechanisms behind the relationships. Clinicians should be aware of these connections to achieve a better understanding and management of MC.
显微镜下结肠炎（MC）是一种大肠的慢性炎症性疾病，作为一种相对较晚才被认识的病症，它与其他胃肠道疾病的关系正逐渐被了解和研究。作为一种多因素疾病，MC通过基因重叠、免疫因素和肠道微生物群与炎症性肠病、乳糜泻和肠易激综合征相互作用。MC患者患结直肠癌的风险显著较低，胃肠道感染会增加患MC的风险，且感染与MC之间存在负相关。MC与其他胃肠道疾病之间存在多种关联，其中基因效应、免疫特征相似性和肠道微生态等方面是这些关系背后的潜在机制。临床医生应了解这些联系，以便更好地理解和管理MC。
