经动脉化疗栓塞术后 CT 容积油沉积能否预测肝脏平滑肌肉瘤转移的磁共振成像治疗反应？

Can Posttransarterial Chemoembolization Volumetric Oil Deposition on Computed Tomography Predict Treatment Response on Magnetic Resonance Imaging in Leiomyosarcoma Metastases to the Liver?

机构信息

From the Russell H. Morgan Department of Radiology and Radiological Sciences.

Division of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.

出版信息

J Comput Assist Tomogr. 2022;46(3):327-332. doi: 10.1097/RCT.0000000000001294. Epub 2022 Apr 8.

DOI:10.1097/RCT.0000000000001294

PMID:35405712

Abstract

OBJECTIVE

To predict early tumor response to transarterial chemoembolization (TACE) based on volumetric oil deposition on posttreatment computed tomography (CT) in patients with leiomyosarcoma liver metastases.

METHODS

This retrospective lesion-by-lesion based study included 32 lesions. The volumetric percent enhancing tumor on pre-TACE and 1-month post-TACE venous phase magnetic resonance imaging (MRI), and the percent oil deposition on CT 1 day after TACE were calculated. The predicted post-TACE enhanced percentage was computed by subtracting percent oil deposition from baseline percent enhanced.

RESULTS

Mean percentage of viable tumor on pre-TACE MRI was 90.6% ± 9.3%. Mean oil deposition was calculated as 51.4% ± 26.2%. Mean percentage of measured residual tumor enhancement 1 month after TACE was 58.3% ± 27%, which correlates with predicted enhancement percentage of 43.9% ± 25.1% (r = 0.72, P < 0.001). A threshold of 35.5% for enhancement reduction was determined to predict tumor response with an accuracy of 78.1%.

CONCLUSION

Volumetric oil deposition on CT can predict residual enhancement on post-TACE MRI.

摘要

目的

基于经导管肝动脉化疗栓塞术（TACE）后 CT 上的油沉积体积，预测平滑肌肉瘤肝转移患者的早期肿瘤反应。

方法

本回顾性基于病变的研究纳入了 32 个病变。计算 TACE 前和 1 个月后静脉期 MRI 的肿瘤增强百分比，以及 TACE 后 1 天 CT 上的油沉积百分比。通过从基线增强百分比中减去油沉积百分比来计算预测 TACE 后的增强百分比。

结果

TACE 前 MRI 上的肿瘤活性百分比平均值为 90.6%±9.3%。油沉积的平均值为 51.4%±26.2%。TACE 后 1 个月测量的残余肿瘤增强百分比的平均值为 58.3%±27%，与预测的增强百分比 43.9%±25.1%（r=0.72，P<0.001）相关。确定增强减少的阈值为 35.5%，以预测肿瘤反应，准确率为 78.1%。