Department of Clinical Pharmacy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
School of Pharmacy, Newcastle University, Newcastle upon Tyne, UK.
Int J Pharm Pract. 2022 May 26;30(2):116-128. doi: 10.1093/ijpp/riac009.
To identify, describe and critically appraise the quality of studies of interventions developed to reduce the rate of secondary care utilisation and investigate interventions' impact on patients with type 2 diabetes mellitus (T2DM).
Using a systematic approach, five databases were searched between 01 January 1995 and 01 February 2021 (MEDLINE, EMBASE, PsycINFO, CINAHL and Cochrane database). Inclusion criteria were studies (published in English) in adults with T2DM offered intervention(s) involving medicines/services/educational programmes in any country or setting, with investigated outcomes including the rate of hospital admission/re-admission/accident and emergency visits. Validated tools were used to assess the quality and accuracy of reporting the interventions. A narrative synthesis was used to frame the findings.
A total of 4670 papers were identified, which yielded a final 53 studies after screening against the inclusion criteria. Identified interventions were complex interventions (n = 21) including at least two interventions (e.g. improving medication adherence and patient education), medication management (n = 15), patient education programmes (n = 8), lifestyle interventions (n = 5) and other interventions (n = 4; e.g. dental care). After assessing for quality and effectiveness of interventions, 15 studies remained; 7 were medication management interventions (e.g. use of insulin pen) and 8 were complex interventions (e.g. pharmaceutical care and telehealth systems). Complex interventions showed significant improvement in clinical outcomes and reduction in secondary care utilisation.
This narrative review identified potential elements of an effective complex intervention to reduce healthcare utilisation in patients with T2DM. These results could inform the development of interventions to be tested for feasibility, before piloting to assess for outcomes that improve diabetic care, reduce diabetes-related complications and minimise healthcare utilisation.
识别、描述和批判性评估旨在降低二级保健利用率的干预措施的研究,并调查干预措施对 2 型糖尿病患者的影响。
使用系统方法,于 1995 年 1 月 1 日至 2021 年 2 月 1 日在五个数据库(MEDLINE、EMBASE、PsycINFO、CINAHL 和 Cochrane 数据库)中进行了检索。纳入标准为在任何国家或环境下对 2 型糖尿病成人提供涉及药物/服务/教育计划的干预措施的研究(以英文发表),调查结果包括住院/再住院/急诊就诊率。使用经过验证的工具评估干预措施的质量和报告准确性。采用叙述性综述来阐述研究结果。
共确定了 4670 篇论文,经过筛选后,最终有 53 项研究符合纳入标准。确定的干预措施为复杂干预措施(n=21),包括至少两项干预措施(如改善药物依从性和患者教育)、药物管理(n=15)、患者教育计划(n=8)、生活方式干预(n=5)和其他干预措施(n=4;如牙科保健)。对干预措施的质量和有效性进行评估后,有 15 项研究仍保留;其中 7 项为药物管理干预措施(如使用胰岛素笔),8 项为复杂干预措施(如药物治疗和远程医疗系统)。复杂干预措施在临床结局改善和二级保健利用率降低方面显示出显著效果。
本叙述性综述确定了 2 型糖尿病患者降低医疗保健利用率的有效复杂干预措施的潜在要素。这些结果可以为开发干预措施提供信息,以便在进行可行性测试之前进行试点,以评估改善糖尿病护理、减少糖尿病相关并发症和最小化医疗保健利用率的结果。