Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
Department of Cardiac Surgery, Emergency Institute for Cardiovascular Diseases "Prof. Dr. C.C. Iliescu", Bucharest, Romania.
Braz J Cardiovasc Surg. 2022 May 23;37(3):306-314. doi: 10.21470/1678-9741-2020-0503.
Functional tricuspid regurgitation (TR) is known to complicate adult atrial septal defect (ASD), but its management is still under debate. We reviewed our experience in ASD surgery, focusing on associated functional TR and its treatment.
This retrospective study (2005-2019) included 206 consecutive adult ASD surgical cases without associated valve pathology, except functional TR. Variables were statistically compared on TR classes and surgery-defined groups.
Mean age of the patients was 40.3±13 years; 19.9% had sinus venosus syndrome. TR severity was directly related to age, pulmonary systolic pressure, right ventricular and tricuspid annulus diameters, and heart failure class. TR ≥ 2 was found in 134 (65%) patients, while TR ≥ 3 in 56 (27.2%) patients. Tricuspid surgery was associated to shunt closure in 66 (32%) patients, almost all through valve repair; indication was directly related to age, right ventricular and tricuspid annulus diameters, and heart failure class ≥ 3. Tricuspid surgery was more efficient than isolated shunt closure in decreasing TR (79±23% vs. 36±26%; P=1.8 E-18). Device closure availability (last four years of the study) was associated with 1/3 reduction of surgical cases but increased the share of cases with TR>2 (> 51% vs. < 31%; P<0.05).
In the era of device closure, surgery for adult ASD is less frequent, but the share of significant TR cases is in net increase. To avoid long-term postoperative TR, we plead for valve repair in all patients with severe TR and for considering repair in moderate TR at risk of persistence.
功能性三尖瓣反流(TR)已知会使成人房间隔缺损(ASD)复杂化,但对其的治疗仍存在争议。我们回顾了我们在 ASD 手术方面的经验,重点关注相关的功能性 TR 及其治疗。
这项回顾性研究(2005-2019 年)纳入了 206 例连续的成人 ASD 手术病例,这些病例除了功能性 TR 外,没有其他相关的瓣膜病变。变量根据 TR 分级和手术定义的组别进行了统计学比较。
患者的平均年龄为 40.3±13 岁,19.9%患有静脉窦综合征。TR 严重程度与年龄、肺动脉收缩压、右心室和三尖瓣环直径以及心力衰竭分级直接相关。134 例(65%)患者存在 TR≥2,56 例(27.2%)患者存在 TR≥3。66 例(32%)患者需要进行三尖瓣手术以关闭分流,几乎所有患者都通过瓣膜修复进行;手术适应证与年龄、右心室和三尖瓣环直径以及心力衰竭分级≥3 直接相关。与单纯分流关闭术相比,三尖瓣手术在降低 TR 方面更有效(79±23%对 36±26%;P=1.8E-18)。器械封堵的可用性(研究的最后四年)与手术病例减少 1/3 相关,但增加了 TR>2 的病例比例(>51%对<31%;P<0.05)。
在器械封堵时代,成人 ASD 的手术治疗频率降低,但严重 TR 病例的比例呈净增加趋势。为了避免长期术后 TR,我们主张对所有严重 TR 患者进行瓣膜修复,并考虑对有持续风险的中度 TR 患者进行修复。