AIIMS, Raipur.
J Assoc Physicians India. 2022 Apr;70(4):11-12.
Autonomic dysfunction associated with Type 2 Diabetes Mellitus is a well known entity, of which cardiac autonomic neuropathy deserves a special mention due to its propensity to cause major cardiac events in a seemingly asymptomatic individual. The incidence of Cardiac autonomic neuropathy among newly diagnosed Diabetes patients is less studied, with most of the current studies done in Western populace who have a different metabolic milieu compared to Indians. This study aims to find the prevalence of cardiac autonomic neuropathy in the Central Indian population, presenting to our center who are diagnosed to be having Diabetes Mellitus within one year.
35 patients, of the age group (18-45 years), who were diagnosed to have Type 2 Diabetes Mellitus within the last one year were taken, after excluding any other chronic illness, like CKD, CLD, CVA, etc. and after getting consent. 35 healthy age and sex-matched controls were included in the study. Cardiac Autonomic Testing was done for all of them, using the measurement of Heart Rate Variability (HRV), Deep Breathing Test (DBT), Cold Pressor Test (CPT), and Lying to Standing Test (LST). The experimental data was analyzed using Labchart Software for autonomic dysfunction.
On preliminary analysis, around 40% of the patients enrolled in the study had cardiac autonomic dysfunction, predominantly parasympathetic dysfunction, compared to the controls. There was no significant age-wise difference in cardiac autonomic dysfunction. There was also no statistically significant correlation with the HbA1c of the patient at presentation and their cardiac autonomic dysfunction.
There is significant cardiac autonomic dysfunction among newly diagnosed Diabetes patients. This reaffirms the fact that early screening and diagnosis of this disease is paramount to prevent significant morbidity and mortality associated with the complications of the disease.
本研究旨在探讨新诊断的糖尿病患者中心血管自主神经病变的患病率。
本研究纳入了年龄在 18-45 岁之间的 35 名新诊断为 2 型糖尿病且在过去一年中被诊断为糖尿病的患者，排除了任何其他慢性疾病，如 CKD、CLD、CVA 等，并获得了同意。同时纳入了 35 名年龄和性别相匹配的健康对照者。对所有参与者进行了心血管自主神经测试，包括心率变异性（HRV）、深呼吸试验（DBT）、冷加压试验（CPT）和卧位到站立位试验（LST）。使用 Labchart 软件分析实验数据以评估自主神经功能障碍。
初步分析显示，与对照组相比，研究中约 40%的患者存在心血管自主神经功能障碍，主要为副交感神经功能障碍。心血管自主神经功能障碍与年龄无显著相关性。此外，患者就诊时的 HbA1c 与其心血管自主神经功能障碍之间也无统计学显著相关性。
新诊断的糖尿病患者中存在显著的心血管自主神经功能障碍。这再次证实了早期筛查和诊断该疾病对于预防与疾病并发症相关的严重发病率和死亡率至关重要。
