研究 2 型糖尿病患者血清腺苷脱氨酶水平与 Hba1c 的相关性。
To Study the Correlation of Serum Adenosine Deaminase Levels with Hba1c in Patients of Type 2 Diabetes Mellitus.
机构信息
Bangalore Medical College and Research Institute, Bangalore.
出版信息
J Assoc Physicians India. 2022 Apr;70(4):11-12.
UNLABELLED
Immunological dysfunction is responsible for increased morbidity and mortality due to recurrent infections and hospital admission in Type 2 DM. There are limited studies and markers for the assessment of immunological dysfunction and serum ADA is one of the marker of immunological dysfunction as proven in several studies.The present study is an attempt to correlate ADA as a marker of altered immune function in diabetes mellitus with respect to glycemic control as assessed by HbA1C.
MATERIAL
This cross sectional study was conducted in the hospitals attached to Bangalore Medical College and Research Institute. Relavant history taken,Clinical examination and laboratory investigations was done on 90 patients of Type 2 Diabetes mellitus,correlation of HbA1c and serum ADA was done in these individuals taking into consideration the glycemic control. Student t test was used to compare them.Spearman's correlation coefficient was used to see the relationship between the variables and p value of <0.05 was considered significant.
OBSERVATION
Among 90 patients in our study 57 were males and 33 were females. Mean ± SD of HbA1C was 9.85± 2.73.Mean ± SD of serum ADA levels was 40.39 ± 4.69. Spearman's correlation coefficient in our study was 0.728 indicating a strong correlation between serum ADA and HbA1C. There was a linear correlation between HbA1C levels and serum ADA and the correlation was statistically significant P Value <0.001.
CONCLUSION
Metabolic and immunological disturbance are two important key factors in type 2 diabetes mellitus which is a leading cause of morbidity and mortality.ADA is an enzyme, which is considered as a good marker for cell mediated immunity.Our study showed elevated serum ADA activity in poorly controlled diabetic individuals and a strong correlation of HbA1C with serum ADA levels which was statistically significant indicating poor the glycemic control more the immunological dysfunction.
目的
探讨 ADA 作为糖尿病患者免疫功能改变的标志物与糖化血红蛋白（HbA1c）评估的血糖控制之间的相关性。
方法
这是一项在班加罗尔医学研究所附属医院进行的横断面研究。对 90 例 2 型糖尿病患者进行了相关病史采集、临床检查和实验室检查，根据血糖控制情况，对这些患者的 HbA1c 和血清 ADA 进行了相关性分析。采用 Student t 检验进行比较，Spearman 相关系数用于观察变量之间的关系，p 值<0.05 为差异有统计学意义。
结果
在我们的研究中，90 例患者中男性 57 例，女性 33 例。HbA1c 的平均值±标准差为 9.85±2.73。血清 ADA 水平的平均值±标准差为 40.39±4.69。Spearman 相关系数为 0.728，表明血清 ADA 与 HbA1C 之间存在很强的相关性。HbA1C 水平与血清 ADA 之间存在线性相关，相关性具有统计学意义（P 值<0.001）。
结论
代谢和免疫紊乱是 2 型糖尿病的两个重要关键因素，是发病率和死亡率的主要原因。ADA 是一种酶，被认为是细胞介导免疫的良好标志物。我们的研究表明，在血糖控制不佳的糖尿病患者中，血清 ADA 活性升高，且 HbA1C 与血清 ADA 水平之间存在很强的相关性，具有统计学意义，表明血糖控制越差，免疫功能障碍越严重。
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