Urinary Citrate and Butyric Acid as Early Biomarkers for Diagnosing Post Stroke Depression in T2dM.

UNLABELLED

Depression can adversely affect the quality of life of type 2 diabetes mellitus(T2DM) patients after stroke. However, there were still no objective methods to diagnose T2DM patients with poststroke depression (PSD). Currently, the diagnosis of depression in T2DM patients after stroke mainly depends on the subjective method (such as Hamilton Depression Rating Scale). But due to its considerably complex and diverse clinical symptoms of depression, this method unavoidably results in a considerable error rate. Our results could be helpful for the development of objective method to diagnose PSD in Type2DM and also provide novel ideas to study the pathogenesis of PSD in Type2DM. Therefore, we conducted this study to deal with this problem. To assess the levels of Urinary Citrate and Butyric acid in Type 2 DM with Post Stroke Depression (PSD) and without Post Stroke Depression (PSD) and To Correlate the levels of same for Objective Diagnosis of PSD in Type2 DM.

MATERIAL

A total of 128 Type2 DM patients with history of stroke for at least 3months were taken into study after obtaining informed consent from them. Using HAM-D (Hamilton Depression Rating Scale) they were divided into 2 groups. One Group included 64 patients of Type 2 DM stroke with Depression and Another group included 64 patients of Type 2 DM stroke without Depression. Urinary Citrate and Butyric acid were measured in both groups using ELISA Kits.

OBSERVATION

Urinary concentrations of Citrate and Butyric Acid showed statistical significance between Type 2 DM with Post Stroke Depression (PSD) and Type 2DM without Post Stroke Depression (PSD), with chi square test values of ϰ2=11.91 for Urinary Citrate (p=0.008), ϰ2= 24.69 for Urinary Butyric acid (p=0.00).

CONCLUSION

Mean levels of Urinary Citrate and Butyric acid were significantly higher in Type 2 Diabetic Stroke with Depression when compared to Type 2 Diabetic Stroke without Depression.