Silchar Medical College and Hospital, Silchar, Assam.
J Assoc Physicians India. 2022 Apr;70(4):11-12.
Diabetes mellitus is a group of common metabolic disorders that share the phenotype of hyperglycaemia. Like most other chronic disorders, diabetes increases the excretion of minerals and other nutrients. Magnesium is a micronutrient and the second most abundant intracellular cation whose concentration remains remarkably constant in healthy subjects. It is known to activate enzymes and act as important cofactor in various biochemical reactions. Also, Magnesium is required for insulin secretion and for proper insulin functioning via tyrosine kinase activity at the receptor level. Therefore, through this study an attempt has been made to evaluate the association between serum magnesium levels and the glycaemic status of these patients as measured in the form of HbA1c.
The study is conducted in the General Medicine ward of a tertiary care hospital in Assam for 4 months, which included 140 patients of Type 2 Diabetes Mellitus. Patients were subjected to history and examination, investigations and analysed using simple statistical methods.
In the present study, HbA1C of >7% was taken as poor glycaemic control and the mean magnesium level in this group was 1.46±0.50 mg/dl and in the group with <7% indicated good glycaemic control, the mean magnesium level was 1.48±0.53 mg/dl. On doing t-test for independent means, the p-value was found to be significant at <0.00001. This shows that patients with poor glycaemic control(HbA1c >7%) have lesser serum magnesium levels as compared to the patients with good glycaemic control(HbA1c <7%).
The present study investigated the serum magnesium levels in patients with Type 2 Diabetes Mellitus and its association with glycated haemoglobin (HbA1c) levels. It was found that the level of magnesium was lower in patients with higher glycated hemoglobin levels. Therefore hypomagnesemia was more in patients with poor glycaemic control. Based on this study, it can be said that magnesium levels can be taken as an indicator of the glycaemic status in the diabetics. Oral magnesium supplementation can be advised in such patients.
评估血清镁水平与糖化血红蛋白（HbA1c）水平之间的关系。
本研究在阿萨姆邦的一家三级护理医院的普通内科病房进行，为期 4 个月，共纳入 140 例 2 型糖尿病患者。对患者进行病史和体格检查、检查和分析，采用简单的统计方法。
在本研究中，将 HbA1C＞7%作为血糖控制不佳的指标，该组的平均镁水平为 1.46±0.50mg/dl；HbA1C＜7%的组表示血糖控制良好，平均镁水平为 1.48±0.53mg/dl。进行独立样本 t 检验，p 值＜0.00001，差异有统计学意义。这表明血糖控制不佳（HbA1c＞7%）的患者血清镁水平低于血糖控制良好（HbA1c＜7%）的患者。
本研究调查了 2 型糖尿病患者的血清镁水平及其与糖化血红蛋白（HbA1c）水平的关系。结果发现，糖化血红蛋白水平较高的患者镁水平较低。因此，血糖控制不佳的患者低镁血症更为常见。基于这项研究，可以说镁水平可以作为糖尿病患者血糖状态的指标。可以建议此类患者口服补充镁。
