VMMC and Safdarjung Hospital, Bhagalpur.
J Assoc Physicians India. 2022 Apr;70(4):11-12.
Non-alcoholic fatty liver disease (NAFLD) is considered a potential independent risk factor for cardiovascular disease. Increased carotid intima-media thickness (CIMT) is a sign of early atherosclerosis and is linked to an increased risk of myocardial infarction, stroke, and peripheral vascular disease.
To study correlation between CIMT and NAFLD and its association with increase in grades of NAFLD. Material and Study Design: An observational case control study of 40 cases and 40 controls (age and sex matched) was done. The difference of CIMT between the two groups was analysed. CIMT was also measured among the various grades of NAFLD cases.
40 cases with NAFLD and 40 controls falling within the age group of 18-45 years were taken in the study. Patients with history of significant alcohol consumption, acute or chronic liver disease, diabetes mellitus, hypertension, malignancy, hypothyroidism and having dyslipidaemia, CAD and stroke were excluded from the study. All the subjects underwent abdominal and carotid ultrasound in order to assess NAFLD and CIMT measurement. The left and right common carotid artery was examined using PHILIPS HD11XE high-definition ultrasound system equipped with a 3-12 MHz linear array transducer in B mode.
There was a statistically significant difference between the 2 groups in terms of CIMT with a p value of <0.001. The mean CIMT in the Case group was 0.86 mm while in Control group was 0.52 mm. There was a significant difference between the 3 Grades of NAFLD in terms of CIMT with a p value of <0.001 with maximum CIMT being in Grade 3 of NAFLD. Body Mass Index, Alanine Transaminase, Aspartate Transaminase, Alkaline Phosphatase, Total Cholesterol, Triglycerides, Low Density Lipoprotein were also found to have statistical significant difference between cases and controls. Age, gender, Blood pressure, Fasting Blood Sugar, HbA1c, Hemoglobin, Total leucocyte Count, Platelet count, Serum Bilirubin, Total protein and Albumin were found to be statistically insignificantly different between cases and controls.
CIMT is increased in NAFLD patients. Increase in CIMT is significantly correlated with increasing grades of NAFLD. Hence CIMT can be used as screening tests in NALFD patients to assess cardiovascular risks.
非酒精性脂肪性肝病（NAFLD）被认为是心血管疾病的一个潜在独立危险因素。颈动脉内膜中层厚度（CIMT）增加是动脉粥样硬化的早期征象，与心肌梗死、中风和外周血管疾病的风险增加有关。
研究 CIMT 与 NAFLD 的相关性及其与 NAFLD 分级增加的关系。
对 40 例病例和 40 例对照（年龄和性别匹配）进行了观察性病例对照研究。分析了两组之间 CIMT 的差异。还测量了不同等级 NAFLD 病例的 CIMT。
研究纳入了 40 例 NAFLD 患者和 40 例年龄在 18-45 岁之间的对照者。排除了有大量饮酒史、急性或慢性肝病、糖尿病、高血压、恶性肿瘤、甲状腺功能减退和血脂异常、冠心病和中风病史的患者。所有患者均行腹部和颈动脉超声检查以评估 NAFLD 和 CIMT 测量。使用 PHILIPS HD11XE 高清晰度超声系统和 B 型 3-12 MHz 线性阵列换能器检查左、右颈总动脉。
两组间 CIMT 有统计学差异，p 值<0.001。病例组平均 CIMT 为 0.86mm，对照组为 0.52mm。NAFLD 三级之间 CIMT 有显著差异，p 值<0.001，NAFLD 三级 CIMT 最大。体重指数、丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶、总胆固醇、甘油三酯、低密度脂蛋白在病例组和对照组之间也有统计学差异。年龄、性别、血压、空腹血糖、HbA1c、血红蛋白、总白细胞计数、血小板计数、血清胆红素、总蛋白和白蛋白在病例组和对照组之间无统计学差异。
NAFLD 患者的 CIMT 增加。CIMT 的增加与 NAFLD 分级的增加显著相关。因此，CIMT 可作为 NAFLD 患者的筛查试验，评估心血管风险。
