Yüksel Cabir, Yenigün Bülent Mustafa, Kocaman Gökhan, Özkıncı Hilal, Kahya Yusuf, Dizbay Sak Serpil, Kayı Cangır Ayten
Department of Thoracic Surgery, Ankara University Faculty of Medicine, Ankara, Turkey.
Medical Pathology, Ankara University Faculty of Medicine, Ankara, Turkey.
Turk Gogus Kalp Damar Cerrahisi Derg. 2022 Jan 28;30(1):101-108. doi: 10.5606/tgkdc.dergisi.2022.21263. eCollection 2022 Jan.
In this study, we aimed to evaluate the clinicopathological features of pulmonary inflammatory myofibroblastic tumor cases operated in our clinic.
A total of 17 inflammatory myofibroblastic tumor patients (5 males, 12 females; median age: 46 years) who were operated in our clinic between February 2000 and July 2019 were included. Data including sex, age, symptoms, accompanying diseases, tumor localization, tumor diameter, endobronchial extension, maximum standard uptake value of the tumors, surgery type, recurrence, and survival data were analyzed.
Two patients were diagnosed preoperatively and two patients were diagnosed during surgery using frozen-section method before resection. Three (17.7%) patients underwent pneumonectomy, five (29.4%) patients lobectomy, three (17.7%) patients segmentectomy, five (29.4%) patients wedge resection, and one (5.8%) patient bronchial sleeve resection. All patients had complete resection with negative margins. None of them had lymph node metastasis. Median follow-up was 122 (range, 8 to 245 months) months. None of the patients received adjuvant therapy, there was no tumor recurrence or tumor-related death.
It is difficult to make a preoperative diagnosis of inflammatory myofibroblastic tumor patients. Systematic lymph node dissection is not required in diagnosed patients. Complete resection is the most important prognostic factor, and it is critical to achieve this with the smallest resection possible.
在本研究中，我们旨在评估在我们诊所接受手术的肺炎性肌纤维母细胞瘤病例的临床病理特征。
纳入2000年2月至2019年7月在我们诊所接受手术的17例炎性肌纤维母细胞瘤患者（5例男性，12例女性；中位年龄：46岁）。分析包括性别、年龄、症状、伴随疾病、肿瘤定位、肿瘤直径、支气管内扩展、肿瘤最大标准摄取值、手术类型、复发和生存数据等资料。
2例患者术前诊断，2例患者在手术切除前采用冰冻切片法在术中诊断。3例（17.7%）患者行肺切除术，5例（29.4%）患者行肺叶切除术，3例（17.7%）患者行肺段切除术，5例（29.4%）患者行楔形切除术，1例（5.8%）患者行支气管袖状切除术。所有患者均实现切缘阴性的完整切除。无一例发生淋巴结转移。中位随访时间为122（范围8至245个月）个月。所有患者均未接受辅助治疗，无肿瘤复发或肿瘤相关死亡。
炎性肌纤维母细胞瘤患者术前诊断困难。确诊患者无需系统性淋巴结清扫。完整切除是最重要的预后因素，尽可能以最小的切除范围实现这一点至关重要。
