MHC 类 II 可在围生期抑制胸腺中 IL-17A Vγ6 γδ T 细胞的生成。
MHC class II inhibits the generation of IL-17A Vγ6 γδ T cells in the thymus at perinatal stage.
机构信息
Division of Immunology and Genome Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga, Japan.
出版信息
Eur J Immunol. 2022 Aug;52(8):1366-1368. doi: 10.1002/eji.202149542. Epub 2022 May 6.
PMID:35446436
Abstract
Vγ6 γδ T cells develop in the thymus at the perinatal stage and are exclusive IL-17A producers among γδ T cells. The loss of MHC class II led to the expansion of IL-17A Vγ6 γδ T cells in the thymus. Thus, MHC class II in the thymus inhibits the generation of IL-17A Vγ6 γδ T cells.
摘要
Vγ6 γδ T 细胞在围生期于胸腺中发育，是 γδ T 细胞中唯一的 IL-17A 产生细胞。MHC Ⅱ类分子的缺失导致胸腺中 IL-17A Vγ6 γδ T 细胞的扩增。因此，胸腺中的 MHC Ⅱ类分子抑制 IL-17A Vγ6 γδ T 细胞的生成。
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