Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou 515063, China.
Department of Pharmacology, Shantou University Medical College, Shantou 515041, China.
J Phys Chem B. 2022 May 5;126(17):3338-3346. doi: 10.1021/acs.jpcb.2c01440. Epub 2022 Apr 21.
Photocages can provide spatial and temporal control to accurately release the various chemicals and bioactive groups when excited by light. Although the absorption spectra of most photocages are in the ultraviolet absorption region, only a few absorb in the visible or near-infrared region. Blebbistatin () would release a hydroxyl radical under blue one-photon or two-photon near-infrared light (800 nm) irradiation. In this work, typical chlorine and bromine as leaving groups substituted hydroxyl compounds (, ) are synthesized to evaluate the photocage's capability of 's platform. Driven by the excited-state charge transfer, and show good photolysis quantum yield to uncage the halogen anion and the uncaging process would be accelerated in water solution. The photochemical reaction, final product's analysis, and femtosecond transient absorption studies on demonstrate that can act as a photocage platform to release the halogen ion via heterolytic reaction when irradiated by blue or near-infrared light. Therefore, can be a new generation of visible or near-infrared light-triggered photocage.
光笼可以提供时空控制，在受到光激发时准确释放各种化学物质和生物活性基团。虽然大多数光笼的吸收光谱在紫外吸收区，但只有少数在可见光或近红外区吸收。blebbistatin（）在蓝光单光子或双光子近红外光（800nm）辐照下会释放羟基自由基。在这项工作中，合成了典型的氯和溴作为离去基团取代的羟基化合物（，），以评估光笼在'的平台上的能力。在激发态电荷转移的驱动下，和显示出良好的光解量子产率，可以解笼化卤素阴离子，并且在水溶液中，解笼化过程会加速。对的光化学反应、最终产物分析和飞秒瞬态吸收研究表明，当用蓝光或近红外光照射时，它可以作为一个光笼平台通过异裂反应释放卤素离子。因此，它可以成为新一代可见光或近红外光触发的光笼。
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