沙特阿拉伯药剂师和医生对儿科人群开具非标签用药处方的认知与看法。
Awareness and Views of Pharmacists and Physicians Toward Prescribing of Drugs for Off-Label Use in the Pediatric Population in Saudi Arabia.
作者信息
Alyami Dawood, Alyami Ajaim A, Alhossan Abdulaziz, Salah Mohammed
机构信息
Department of Pharmacy, Riyadh Elm University, Riyadh, SAU.
Pharmaceutical Care Services, Khobash General Hospital, Najran, SAU.
出版信息
Cureus. 2022 Mar 11;14(3):e23082. doi: 10.7759/cureus.23082. eCollection 2022 Mar.
BACKGROUND
Prescribing off-label drugs in healthcare settings is a common practice worldwide. Thus, it is crucial to evaluate the knowledge and views of healthcare professionals regarding the off-label use of drugs in pediatric patients.
METHODOLOGY
A cross-sectional study was conducted from June to December, 2020, among physicians and pharmacists in the Kingdom of Saudi Arabia (KSA). A 28-item questionnaire was distributed to the healthcare professionals through an electronic link. Descriptive and inferential statistics were used to report the data.
RESULTS
A total of 368 questionnaires were included in the final analysis. More than two-thirds of the respondents were aware of the correct definition of off-label drugs. Of the respondents, 37% were satisfied with their knowledge related to the use of off-label drugs in the pediatric population. Approximately half of the healthcare professionals in the study had major concerns about the efficacy and safety of off-label prescribing to children.
CONCLUSION
Off-label drug use among pediatric patients is common practice in the KSA and healthcare professionals providing treatment to the children are also aware of the concept of off-label drugs.
背景
在医疗环境中开具未标明适应症用药是全球普遍存在的做法。因此，评估医疗专业人员关于儿科患者未标明适应症用药的知识和观点至关重要。
方法
2020年6月至12月在沙特阿拉伯王国（KSA）的医生和药剂师中开展了一项横断面研究。通过电子链接向医疗专业人员发放了一份包含28个条目的问卷。采用描述性和推断性统计方法汇报数据。
结果
最终分析纳入了总共368份问卷。超过三分之二的受访者知晓未标明适应症用药的正确定义。在受访者中，37%对其关于儿科人群未标明适应症用药的知识感到满意。该研究中约一半的医疗专业人员对给儿童开具未标明适应症用药的疗效和安全性存在重大担忧。
结论
在沙特阿拉伯王国，儿科患者使用未标明适应症用药是常见做法，为儿童提供治疗的医疗专业人员也知晓未标明适应症用药的概念。
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