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靶向NAD⁺：这是延缓心脏衰老的常见策略吗？

Targeting NAD+: is it a common strategy to delay heart aging?

作者信息

Yuan Yang, Liang Bing, Liu Xin-Lin, Liu Wen-Jing, Huang Bing-Huan, Yang Shan-Bo, Gao Yuan-Zhen, Meng Jing-Sen, Li Meng-Jiao, Ye Ting, Wang Chuan-Zhi, Hu Xiao-Kun, Xing Dong-Ming

机构信息

Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute, Qingdao, China.

Interventional Medicine Center, Affiliated Hospital of Qingdao University, Qingdao, China.

出版信息

Cell Death Discov. 2022 Apr 26;8(1):230. doi: 10.1038/s41420-022-01031-3.

DOI:10.1038/s41420-022-01031-3
PMID:35474295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9042931/
Abstract

Heart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numerous studies with NAD+ supplementations have suggested its use in anti-aging treatment. However, systematic reviews regarding the overall role of NAD+ in cardiac aging are scarce. The relationship between NAD+ signaling and heart aging has yet to be clarified. This review comprehensively summarizes the current studies on the role of NAD+ signaling in delaying heart aging from the following aspects: the influence of NAD+ supplementations on the aging heart; the relationship and cross-talks between NAD+ signaling and other cardiac aging-related signaling pathways; Importantly, the therapeutic potential of targeting NAD+ in delaying heart aging will be discussed. In brief, NAD+ plays a vital role in delaying heart aging. However, the abnormalities such as altered glucose and lipid metabolism, oxidative stress, and calcium overload could also interfere with NAD+ function in the heart. Therefore, the specific physiopathology of the aging heart should be considered before applying NAD+ supplementations. We believe that this article will help augment our understanding of heart aging mechanisms. In the meantime, it provides invaluable insights into possible therapeutic strategies for preventing age-related heart diseases in clinical settings.

摘要

心脏衰老（心脏老化）是冠心病的主要易感因素，会显著增加心力衰竭的风险，尤其是当衰老的心脏遭受缺血再灌注损伤时。大量关于补充烟酰胺腺嘌呤二核苷酸（NAD+）的研究表明其可用于抗衰老治疗。然而，关于NAD+在心脏衰老中的整体作用的系统综述却很匮乏。NAD+信号传导与心脏衰老之间的关系尚未阐明。本综述从以下几个方面全面总结了目前关于NAD+信号传导在延缓心脏衰老中作用的研究：补充NAD+对衰老心脏的影响；NAD+信号传导与其他心脏衰老相关信号通路之间的关系及相互作用；重要的是，还将讨论靶向NAD+在延缓心脏衰老方面的治疗潜力。简而言之，NAD+在延缓心脏衰老中起着至关重要的作用。然而，葡萄糖和脂质代谢改变、氧化应激和钙超载等异常情况也可能干扰心脏中的NAD+功能。因此，在应用NAD+补充剂之前应考虑衰老心脏的具体病理生理学。我们相信本文将有助于加深我们对心脏衰老机制的理解。同时，它为临床环境中预防与年龄相关的心脏病的可能治疗策略提供了宝贵的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c2d/9042931/4235ee384913/41420_2022_1031_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c2d/9042931/38a391128ef9/41420_2022_1031_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c2d/9042931/4235ee384913/41420_2022_1031_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c2d/9042931/38a391128ef9/41420_2022_1031_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c2d/9042931/42f93ad16326/41420_2022_1031_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c2d/9042931/bd540b51fef8/41420_2022_1031_Fig3_HTML.jpg
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