通过S2取代/缩合/互变异构级联反应制备6-羟基中氮茚及相关咪唑并[1,5 -]吡啶。
Access to 6-hydroxy indolizines and related imidazo[1,5-]pyridines through the S2 substitution/condensation/tautomerization cascade process.
作者信息
Duan Guiyun, Liu Hao, Zhang Liqing, Yuan Chunhao, Li Yongchao, Ge Yanqing
机构信息
Department of Pharmacy, Shandong First Medical University, Shandong Academy of Medical Sciences Taian Shandong 271016 P. R. China
出版信息
RSC Adv. 2021 Jul 23;11(41):25624-25627. doi: 10.1039/d1ra04425g. eCollection 2021 Jul 19.
Abstract
A simple and efficient cascade reaction was developed for the construction of hydroxy substituted indolizines from pyrrole-2-carbaldehydes and commercially available 4-halogenated acetoacetic esters. Their optical properties were also evaluated.
摘要
开发了一种简单有效的级联反应，用于从吡咯-2-甲醛和市售的4-卤代乙酰乙酸酯构建羟基取代的中氮茚。还评估了它们的光学性质。
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