Division of Vaccine Preventable Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
International Vaccine Institute, Seoul, Republic of Korea.
PLoS One. 2022 Apr 28;17(4):e0267294. doi: 10.1371/journal.pone.0267294. eCollection 2022.
Human papillomavirus (HPV) is a common infection principally spread through sexual activity. Most HPV infections are asymptomatic and resolve spontaneously. However, persistent infection may progress to cervical cancer. Highly efficacious HPV vaccines have been available since 2006, yet uptake into national programs has been slow in part due to cost. WHO guidelines call for a two-dose (0,6 month) schedule for girls 9-14 years of age. Post-hoc analyses of randomized trials have found high vaccine effectiveness following a single dose of vaccine. In order to provide additional data on the potential impact of single dose HPV vaccination in a real-world setting, we are conducting an effectiveness study among Thai schoolgirls. This is an observational study of a single dose (SD) or two doses (2D) of the bivalent HPV vaccine CERVARIX® (GlaxoSmithKline plc.) administered in a school-based program to 8-9,000 Grade 8 female students in two provinces of Thailand beginning in 2018; one province is assigned the SD, and the other the standard 2D regimen. The reduction in HPV vaccine-type prevalence will be assessed in each province two and four years after vaccination by comparing HPV prevalence in urine samples obtained through cross-sectional surveys of the immunized grade cohort as they age and compared to a historical "baseline" HPV prevalence of same age students.
人乳头瘤病毒（HPV）是一种常见的感染，主要通过性活动传播。大多数 HPV 感染是无症状的，会自行消退。然而，持续感染可能会进展为宫颈癌。自 2006 年以来，高效的 HPV 疫苗已经问世，但由于成本原因，在国家计划中的接种率一直很慢。世卫组织指南呼吁为 9-14 岁的女孩接种两剂（0、6 个月）疫苗。随机试验的事后分析发现，一剂疫苗接种后疫苗具有很高的有效性。为了提供更多关于在现实环境中单剂量 HPV 疫苗接种潜在影响的数据，我们正在泰国女学生中开展一项疫苗有效性研究。这是一项观察性研究，在泰国两个省的学校计划中，对 8000 至 9000 名 8 年级的女学生接种一剂（SD）或两剂（2D）二价 HPV 疫苗 CERVARIX®（葛兰素史克公司）；其中一个省分配 SD，另一个省分配标准的 2D 方案。在接种疫苗两年和四年后，通过比较免疫接种年级队列的尿液样本中的 HPV 流行率，评估每个省的 HPV 疫苗型流行率，这些样本是通过对年龄较大的免疫学生进行横断面调查获得的，并与同年龄学生的历史“基线”HPV 流行率进行比较。
