Department of Biomedicine, University of Basel, Basel, Switzerland; Department of Surgery, University Hospital Basel, Basel, Switzerland.
Department of Biomedicine, University of Basel, Basel, Switzerland.
Trends Cell Biol. 2022 Oct;32(10):854-867. doi: 10.1016/j.tcb.2022.03.007. Epub 2022 Apr 25.
Most solid cancer-related deaths result from metastasis, a multistep process in which cancer cells exit the primary site, intravasate into the bloodstream, extravasate, and colonize distant organs. Colonization is facilitated by clonal selection and the high phenotypic plasticity of cancer cells that creates reversible switching of cellular states. Cancer cell plasticity leads to intratumor heterogeneity and fitness, yielding cells with molecular and cellular programs that facilitate survival and colonization. While cancer cell plasticity is sometimes limited to the process of epithelial-to-mesenchymal transition (EMT), recent studies have broadened its definition. Plasticity arises from both cell-intrinsic and cell-extrinsic factors and is a major obstacle to efficacious anti-cancer therapies. Here, we discuss the multifaceted notion of cancer cell plasticity associated with metastatic colonization.
大多数与实体瘤相关的死亡是由转移引起的，转移是一个多步骤的过程，其中癌细胞从原发部位逸出，进入血流，逸出并在远处器官定植。克隆选择和癌细胞的高表型可塑性促进了定植，这导致了细胞状态的可逆转换。癌细胞的可塑性导致肿瘤内异质性和适应性，产生具有促进存活和定植的分子和细胞程序的细胞。虽然癌细胞的可塑性有时仅限于上皮-间充质转化（EMT）过程，但最近的研究已经拓宽了其定义。可塑性源自细胞内和细胞外因素，是有效抗癌治疗的主要障碍。在这里，我们讨论与转移定植相关的癌细胞可塑性的多方面概念。
