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日本社区居住的老年人中人格特质与多种药物治疗的关联:SONIC 研究数据的横断面分析。

Association of personality traits with polypharmacy among community-dwelling older adults in Japan: a cross-sectional analysis of data from the SONIC study.

机构信息

Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, Japan.

Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.

出版信息

BMC Geriatr. 2022 Apr 28;22(1):372. doi: 10.1186/s12877-022-03069-5.

Abstract

BACKGROUND

Polypharmacy is a serious concern among older adults and is frequently related to adverse outcomes, including health problems, reduced quality of life, and increased medical expenses. Although personality traits are associated with health behaviors and diseases, the effect of polypharmacy on personality traits is unclear. Therefore, we examined the association of personality traits with polypharmacy among community-dwelling older adults.

METHODS

This cross-sectional study analysed data on 836 community-dwelling older adults aged 69-71 years who participated in the Japanese longitudinal cohort study of Septuagenarians, Octogenarians, and Nonagenarians Investigation with Centenarians. Polypharmacy was defined as the intake of ≥ 5 medications concurrently. Personality traits were assessed using the Japanese version of the NEO-Five-Factor Inventory (NEO-FFI). A five-factor model of personality traits, including "neuroticism," "extraversion," "openness," "agreeableness," and "conscientiousness," was measured by the NEO-FFI.

RESULTS

The average number of medications was about 3 in both men and women. Among the participants, polypharmacy was observed in 23.9% of men and 28.0% of women. Multivariable logistic regression analysis showed that neuroticism (adjusted odds ratio [aOR] per 1 point increase = 1.078, 95% confidence interval [CI] = 1.015-1.144) in men and extraversion (aOR = 0.932, 95% CI = 0.884-0.983) in women were associated with polypharmacy.

CONCLUSIONS

Higher neuroticism in men and lower extraversion in women were associated with polypharmacy. This study suggests that personality traits may be involved in the process leading to the development of polypharmacy. Information on individual personality traits may help medical professionals in decision-making regarding medication management for lifestyle-related diseases.

摘要

背景

老年人普遍存在多重用药问题,这与多种不良后果相关,包括健康问题、生活质量下降和医疗费用增加。虽然个性特征与健康行为和疾病有关,但多重用药对个性特征的影响尚不清楚。因此,我们研究了社区老年人的个性特征与多重用药之间的关系。

方法

这项横断面研究分析了参加日本 70、80、90 岁及以上和百岁老人纵向研究的 836 名 69-71 岁社区居住老年人的数据。多重用药定义为同时服用≥5 种药物。个性特征采用日本版 NEO 五因素人格量表(NEO-FFI)进行评估。NEO-FFI 测量了个性特征的五因素模型,包括“神经质”、“外向性”、“开放性”、“宜人性”和“尽责性”。

结果

男性和女性平均服用的药物数量约为 3 种。在参与者中,男性中有 23.9%和女性中有 28.0%存在多重用药。多变量逻辑回归分析显示,男性的神经质(每增加 1 分,调整后的优势比[aOR]为 1.078,95%置信区间[CI]为 1.015-1.144)和女性的外向性(aOR 为 0.932,95%CI 为 0.884-0.983)与多重用药相关。

结论

男性神经质较高和女性外向性较低与多重用药相关。本研究表明,个性特征可能参与了导致多重用药发生的过程。关于个体个性特征的信息可能有助于医疗保健专业人员在管理与生活方式相关的疾病的药物治疗方面做出决策。

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