Department of Pharmacy, UNC Health, Chapel Hill, North Carolina, USA.
Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
Pediatr Pulmonol. 2022 Jul;57(7):1814-1817. doi: 10.1002/ppul.25946. Epub 2022 May 14.
This pilot study successfully implemented a standardized protocol for tablet-based ototoxicity screening in pediatric cystic fibrosis (CF) patients exposed to aminoglycosides. Further studies are needed to assess the impact of implementation in a larger number of patients, as well as to determine barriers that may exist at centers with variation in available resources. This method of ototoxicity screening represents an accessible alternative to traditional audiology testing, and given the continued improvements in expected life span for people with CF, it is imperative that patients have regular access to this type of screening to allow for early identification of medication-related toxicities.
本初步研究成功实施了标准化的平板电脑测听方案,用于检测接受氨基糖苷类药物治疗的囊性纤维化(CF)儿科患者的耳毒性。需要进一步研究来评估在更多患者中实施该方案的效果,以及确定在资源存在差异的中心可能存在的障碍。这种耳毒性筛选方法是传统听力学测试的一种可行替代方法,鉴于 CF 患者的预期寿命持续延长,患者必须定期进行这种类型的筛选,以便及早发现与药物相关的毒性。