血清尿酸对冠状动脉旁路移植术后房颤的影响

The Impact of Serum Uric Acid on Postoperative Atrial Fibrillation in Coronary Artery Bypass Graft.

作者信息

Zhang Qian, Wei Yangyan, Huang Siyang, Tang Jiwen, Chang Qing

机构信息

Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, China.

出版信息

Heart Surg Forum. 2022 Apr 29;25(2):E320-E325. doi: 10.1532/hsf.4603.

DOI:10.1532/hsf.4603

PMID:35486042

Abstract

BACKGROUND

Postoperative atrial fibrillation (POAF) after cardiac surgery is a common complication. We aimed to investigate the impact of serum uric acid level (UA) on the POAF of patients undergoing coronary artery bypass grafting (CABG).

METHODS

A retrospective cohort study of patients undergoing CABG at the Hospital between January 2019 and December 2019 was performed. Hyperuricemia (HUA) was defined as serum UA levels >420 µmol/l in men and>360 µmol/l in women. The included patients were divided into the HUA group (103) and the normal UA group (306) based on serum uric acid levels before surgery. POAF was defined as atrial fibrillation that occurred within 7 days of cardiac surgery. We use COX regression analysis and Kaplan-Meier curves (log-rank test) for statistical analysis.

RESULTS

The incidence of HUA was 25.2% (103/409). The rate of POAF was 28.61%. Univariate COX regression analysis showed the risk of POAF occurrence. It was revealed that UA was an independent predictor of POAF (HR=1.493, 95% CI1.007-2.212, P = 0.046). Kaplan-Meier curves showed that high serum UA was associated with the occurrence of POAF (P = 0.034). Moreover, age (HR=1.05, 95%CI 1.024-1.076, P < 0.001), AD (HR=1.567, 95%CI .015-2.42, P = 0.043), and CCB (HR=0.647, 95%CI 0.424-0.988, P = 0.044) also were independent predictors of POAF.

CONCLUSIONS

Preoperative UA level was significantly associated with POAF. Higher serum UA was an independent risk factor for POAF.

摘要

背景

心脏手术后的术后房颤（POAF）是一种常见并发症。我们旨在研究血清尿酸水平（UA）对接受冠状动脉旁路移植术（CABG）患者POAF的影响。

方法

对2019年1月至2019年12月在该医院接受CABG的患者进行回顾性队列研究。高尿酸血症（HUA）定义为男性血清UA水平>420µmol/l，女性>360µmol/l。根据术前血清尿酸水平，将纳入的患者分为HUA组（103例）和正常UA组（306例）。POAF定义为心脏手术后7天内发生的房颤。我们使用COX回归分析和Kaplan-Meier曲线（对数秩检验）进行统计分析。

结果

HUA的发生率为25.2%（103/409）。POAF的发生率为28.61%。单因素COX回归分析显示了POAF发生的风险。结果显示，UA是POAF的独立预测因子（HR=1.493，95%CI1.007-2.212，P=0.046）。Kaplan-Meier曲线显示，高血清UA与POAF的发生相关（P=0.034）。此外，年龄（HR=1.05，95%CI 1.024-1.076，P<0.001）、AD（HR=1.567，95%CI.015-2.42，P=0.043）和CCB（HR=0.647，95%CI 0.424-0.988，P=0.044）也是POAF的独立预测因子。