肝肾联合移植

Simultaneous Liver-Kidney Transplantation.

作者信息

Nair Gayatri, Nair Vinay

机构信息

Division of Kidney Disease and Hypertension, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, 400 Community Drive, Manhasset, NY 11030, USA.

出版信息

Clin Liver Dis. 2022 May;26(2):313-322. doi: 10.1016/j.cld.2022.01.011. Epub 2022 Apr 1.

DOI:10.1016/j.cld.2022.01.011

PMID:35487613

Abstract

End-stage kidney disease (ESKD) after liver transplantation is associated with high morbidity and mortality. This increase in mortality can be offset by performing a kidney transplant at the time of the liver transplant in select cases. Accordingly, Margreiter and colleague; s performed the first simultaneous liver-kidney (SLK) transplant in 1983. The number of SLK transplants has increased by more than 300% since then. In 1990%, 1.7% of all liver transplants in the United States were SLK transplants which increased to 9.9% by 2016. This steep increase was likely due to the implementation of the model of end-stage liver disease (MELD) scoring system in 2002, which is heavily weighted by serum creatinine.

摘要

肝移植后终末期肾病（ESKD）与高发病率和死亡率相关。在某些情况下，通过在肝移植时进行肾移植可以抵消这种死亡率的增加。因此，1983年Margreiter及其同事进行了首例同期肝肾（SLK）联合移植。从那时起，SLK联合移植的数量增加了300%以上。在1990年，美国所有肝移植中有1.7%是SLK联合移植，到2016年这一比例增至9.9%。这种急剧增加可能是由于2002年实施了终末期肝病模型（MELD）评分系统，该系统中血清肌酐占比很大。