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Melatonin affects red deer spermatozoa motility and physiology in capacitating and non-capacitating conditions.褪黑素影响处于获能和非获能状态下的赤鹿精子的运动和生理机能。
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2
Melatonin Non-Linearly Modulates Bull Spermatozoa Motility and Physiology in Capacitating and Non-Capacitating Conditions.褪黑素非线 性调节牛精子在获能和非获能条件下的运动和生理。
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引用本文的文献

1
and as Non-Seasonal/Seasonal Models for the Role of Melatonin Receptors in the Spermatozoon.以及非季节性/季节性模型在精子中褪黑素受体作用。
Int J Mol Sci. 2022 Jun 3;23(11):6284. doi: 10.3390/ijms23116284.

本文引用的文献

1
Melatonin Non-Linearly Modulates Bull Spermatozoa Motility and Physiology in Capacitating and Non-Capacitating Conditions.褪黑素非线 性调节牛精子在获能和非获能条件下的运动和生理。
Int J Mol Sci. 2020 Apr 13;21(8):2701. doi: 10.3390/ijms21082701.
2
Presence of melatonin-catabolizing non-specific enzymes myeloperoxidase and indoleamine 2,3-dioxygenase in the ram reproductive tract.褪黑素分解代谢非特异性酶髓过氧化物酶和吲哚胺2,3-双加氧酶在公羊生殖道中的存在。
Reprod Domest Anim. 2019 Dec;54(12):1643-1650. doi: 10.1111/rda.13574. Epub 2019 Oct 28.
3
Melatonin reduces cAMP-stimulated capacitation of ram spermatozoa.褪黑素可降低环磷酸腺苷刺激的公羊精子获能。
Reprod Fertil Dev. 2019 Jan;31(2):420-431. doi: 10.1071/RD18087.
4
Melatonin MT₁ and MT₂ Receptors in the Ram Reproductive Tract.褪黑素MT₁和MT₂受体在公羊生殖道中的研究
Int J Mol Sci. 2017 Mar 19;18(3):662. doi: 10.3390/ijms18030662.
5
Melatonin receptors MT1 and MT2 are expressed in spermatozoa from several seasonal and nonseasonal breeder species.褪黑素受体MT1和MT2在几种季节性和非季节性繁殖物种的精子中表达。
Theriogenology. 2016 Nov;86(8):1958-68. doi: 10.1016/j.theriogenology.2016.06.016. Epub 2016 Jun 23.
6
Evidence of melatonin synthesis in the ram reproductive tract.褪黑素在公羊生殖道中合成的证据。
Andrology. 2016 Jan;4(1):163-71. doi: 10.1111/andr.12117. Epub 2016 Jan 6.
7
CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization.CRISP1作为一种新型的CatSper调节剂，在受精过程中调节精子活力和方向。
J Cell Biol. 2015 Sep 28;210(7):1213-24. doi: 10.1083/jcb.201412041.
8
Melatonin in sperm biology: breaking paradigms.褪黑素在精子生物学中的作用：突破传统观念
Reprod Domest Anim. 2014 Oct;49 Suppl 4:11-21. doi: 10.1111/rda.12378.
9
Melatonin protects human spermatozoa from apoptosis via melatonin receptor- and extracellular signal-regulated kinase-mediated pathways.褪黑素通过褪黑素受体和细胞外信号调节激酶介导的途径保护人精子免受细胞凋亡。
Fertil Steril. 2011 Jun;95(7):2290-6. doi: 10.1016/j.fertnstert.2011.03.063. Epub 2011 Apr 16.
10
Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function.富含半胱氨酸的分泌蛋白 4 是瞬时受体电位 M8 的抑制剂，在建立精子功能方面发挥作用。
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7034-9. doi: 10.1073/pnas.1015935108. Epub 2011 Apr 11.

褪黑素影响处于获能和非获能状态下的赤鹿精子的运动和生理机能。

Melatonin affects red deer spermatozoa motility and physiology in capacitating and non-capacitating conditions.

机构信息

Bianor Biotech SL, León, Spain.

Institute for Animal Health and Cattle Development (INDEGSAL) and IMAPOR Research Group, Universidad de León, León, Spain.

出版信息

Reprod Domest Anim. 2022 Oct;57 Suppl 5(Suppl 5):82-85. doi: 10.1111/rda.14137. Epub 2022 May 4.

DOI:10.1111/rda.14137
PMID:35488500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9790586/
Abstract

Melatonin affects sperm physiology, possibly through membrane receptors. Effects were tested at low concentrations (1 pM, 100 pM, 10 nM and 1 µM) in red deer epididymal spermatozoa as a model for high-seasonality species. Samples were incubated with melatonin as uncapacitated or capacitating conditions (heparin) and evaluated for motility and physiology (flow cytometry). Most effects occurred at low concentrations (nM-pM), mainly protecting from apoptosis and maintaining acrosomal integrity, suggesting a role for membrane receptors rather than a direct antioxidant effect. Intracellular calcium was not affected, differing from other studies and perhaps because of the epididymal origin. This study supports the relevance of melatonin on sperm physiology and could contribute to the application of reproductive technologies in wild ruminants.

摘要

褪黑素影响精子生理机能，可能是通过细胞膜受体实现的。本研究以季节性较强的赤鹿精子为模型，在低浓度（1 pM、100 pM、10 nM 和 1 µM）下检测了褪黑素的作用。将样品用褪黑素孵育，不诱导顶体反应（肝素）或诱导顶体反应（肝素），并通过流式细胞术评估运动能力和生理机能。大多数作用发生在低浓度（nM-pM）下，主要是保护精子免受凋亡并维持顶体完整性，这表明膜受体发挥了作用，而不是直接的抗氧化作用。细胞内钙离子不受影响，这与其他研究不同，可能是因为这是附睾来源的精子。本研究支持褪黑素对精子生理机能的重要性，这可能有助于在野生反刍动物中应用生殖技术。