Department of Orthopedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Department of Advanced Technology in Medicine, Graduate School of Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Clin Neurophysiol. 2022 Jul;139:1-8. doi: 10.1016/j.clinph.2022.03.021. Epub 2022 Apr 9.
To measure the neuromagnetic fields of carpal tunnel syndrome patients after electrical digital nerve stimulation and evaluate median nerve function with high spatial resolution.
A superconducting quantum interference device magnetometer system was used to record neuromagnetic fields at the carpal tunnel after electrical stimulation of the middle digital nerve in 10 hands of nine patients with carpal tunnel syndrome. The patients were diagnosed based on symptoms (numbness, tingling, and pain) supported by a positive Phalen or Tinel sign. A novel technique was applied to remove stimulus-induced artifacts, and current distributions were calculated using a spatial filter algorithm and superimposed on X-ray.
In 6 of the 10 hands, the amplitude of the inward current waveform attenuated to <70% or the nerve conduction velocity was <40 m/s. The results of conventional nerve conduction studies were normal for two of these six hands. All four hands that could not be diagnosed by magnetoneurography had severe carpal tunnel syndrome superimposed on peripheral neuropathy secondary to comorbidities.
Technical improvements enabled magnetoneurography to noninvasively visualize the electrophysiological nerve activity in carpal tunnel syndrome patients.
Magnetoneurography may have the potential to contribute to the detailed diagnosis of various peripheral nerve disorders.
测量电数字神经刺激后腕管综合征患者的神经磁场，并利用高空间分辨率评估正中神经功能。
使用超导量子干涉器件磁强计系统记录了 9 名腕管综合征患者的 10 只手中 10 只手的正中神经在电刺激中间数字神经后的神经磁场。根据症状（麻木、刺痛和疼痛）和阳性 Phalen 或 Tinel 征诊断患者。应用一种新的技术来去除刺激引起的伪迹，并使用空间滤波器算法计算电流分布，并叠加在 X 光上。
在 10 只手中的 6 只手，内向电流波形的振幅衰减至<70%或神经传导速度<40 m/s。其中 6 只手中的 2 只常规神经传导研究结果正常。无法通过磁神经图诊断的 4 只手均伴有合并症引起的严重腕管综合征和周围神经病变。
技术改进使磁神经图能够无创地可视化腕管综合征患者的电生理神经活动。
磁神经图可能有潜力有助于各种周围神经疾病的详细诊断。
