乙型肝炎病毒感染对妊娠糖尿病妇女母婴结局的影响：一项为期三年的回顾性研究。

Impact of hepatitis B virus infection on maternal and infant outcomes of women with gestational diabetes mellitus: A three-year retrospective study.

机构信息

School of Nursing, Wuhan University, No.115, Donghu Road, Wuchang District, Wuhan, 430071, Hubei Province, China.

Obstetrics Department, Chongqing Health Center for Women and Children, No.120, Longshan Road, Yubei District, 400021, Chongqing Province, China.

出版信息

J Diabetes Complications. 2022 Jun;36(6):108201. doi: 10.1016/j.jdiacomp.2022.108201. Epub 2022 Apr 20.

DOI:10.1016/j.jdiacomp.2022.108201

PMID:35491310

Abstract

AIMS

To explore the impact of HBV infection on maternal and infant outcomes of GDM women.

METHODS

We retrospectively identified 8126 women with GDM in China from July 2017 to June 2020, and divided them into GDM with HBV infection group (n = 483) and GDM with non-HBV infection group (n = 7643). Two sample t-test and Chi-square test were used to compare differences between groups. Logistic regression models were used to explore the association between HBV infection and maternal and infant outcomes.

RESULTS

Placental abruption (PA), (2.3% vs. 1.0%, P = 0.008), placenta previa (4.3% vs. 2.8% p = 0.044), intrahepatic cholestasis of pregnancy (ICP), (6.4% vs. 3.0%, P < 0.001), cesarean section (52.0% vs. 46.0%, P = 0.011), fetal chromosomal abnormalities (1.2% vs. 0.4%, P = 0.021), and neonatal hyperglycemia (1.9% vs. 3.6%, P = 0.047) were more likely to occur in GDM with HBV infection group. After adjusting for the covariates, HBV infection was found to be associated with ICP (aOR, 2.35; 95% CI: [1.58-3.50]), PA (aOR, 2.34; 95% CI: 1.22-4.47), and fetal chromosomal abnormalities (aOR, 2.88; 95% CI: 1.18-7.03).

CONCLUSIONS

HBV infection was associated with part of maternal and infant outcomes in the GDM population.

摘要

目的

探讨乙型肝炎病毒（HBV）感染对妊娠糖尿病（GDM）女性母婴结局的影响。

方法

我们回顾性地纳入了 2017 年 7 月至 2020 年 6 月期间在中国就诊的 8126 例 GDM 患者，并将其分为 HBV 感染组（n=483）和非 HBV 感染组（n=7643）。采用两样本 t 检验和卡方检验比较两组间的差异。采用 logistic 回归模型探讨 HBV 感染与母婴结局的关系。

结果

HBV 感染组胎盘早剥（PA）（2.3%比 1.0%，P=0.008）、前置胎盘（4.3%比 2.8%，P=0.044）、妊娠肝内胆汁淤积症（ICP）（6.4%比 3.0%，P<0.001）、剖宫产（52.0%比 46.0%，P=0.011）、胎儿染色体异常（1.2%比 0.4%，P=0.021）和新生儿高血糖症（1.9%比 3.6%，P=0.047）的发生率更高。在校正了协变量后，发现 HBV 感染与 ICP（aOR，2.35；95%CI：[1.58-3.50]）、PA（aOR，2.34；95%CI：1.22-4.47）和胎儿染色体异常（aOR，2.88；95%CI：1.18-7.03）相关。