转运RNA衍生的小RNA的功能及治疗意义
Function and Therapeutic Implications of tRNA Derived Small RNAs.
作者信息
Wilson Briana, Dutta Anindya
机构信息
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, United States.
Department of Genetics, University of Alabama, Birmingham, AL, United States.
出版信息
Front Mol Biosci. 2022 Apr 13;9:888424. doi: 10.3389/fmolb.2022.888424. eCollection 2022.
tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from nascent RNA silencing, to post-transcriptional gene silencing, and finally, to translational regulation. The length distribution, sequence diversity, and multifaceted functions of tRFs and tiRs positions them as attractive new models for small RNA therapeutics. In this review, we will discuss the principles of tRF biogenesis and function in order to highlight their therapeutic potential.
转运RNA衍生的小RNA主要由转运RNA片段（tRFs）和半转运RNA（tiRs）组成。自首次被鉴定以来，tRFs和tiRs已被赋予多种功能，涵盖了中心法则调控的各个方面：从新生RNA沉默到转录后基因沉默，最终到翻译调控。tRFs和tiRs的长度分布、序列多样性及多方面功能使其成为小RNA疗法颇具吸引力的新模型。在本综述中，我们将讨论tRF生物合成和功能的原理，以突出它们的治疗潜力。
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