前列环素在溶液中的稳定性研究。
Stability study of prostacyclin in solution.
作者信息
Rácz I, Mezei J, Küttel S
出版信息
Pharmazie. 1986 Nov;41(11):769-71.
PMID:3550821
Abstract
The proton-catalyzed hydrolytic decomposition of prostacyclin was assayed by UV spectroscopic and HPLC methods. Changes of the absorbance in aqueous solutions were measured at 220 nm. HPLC studies were performed on C18 column using NH4Cl (0.03 mol X l-1)/NH4OH (0.03 mol X l-1)/methanol (1 : 1 : 4) eluent. Temperature and pH dependence of the hydrolytic process was determined. Effects of alcohol and glycols on the degradation rate were studied.
摘要
采用紫外光谱法和高效液相色谱法测定了前列环素的质子催化水解分解。在220nm处测量水溶液中吸光度的变化。高效液相色谱研究在C18柱上进行，使用NH4Cl（0.03mol·L-1）/NH4OH（0.03mol·L-1）/甲醇（1:1:4）洗脱液。测定了水解过程的温度和pH依赖性。研究了醇类和二醇类对降解速率的影响。
相似文献
1
Stability study of prostacyclin in solution.
Pharmazie. 1986 Nov;41(11):769-71.
2
The aqueous stability of bupropion.
J Pharm Biomed Anal. 2010 Nov 2;53(3):376-81. doi: 10.1016/j.jpba.2010.04.024. Epub 2010 May 4.
3
Stability of new analgesic active compound, pyrrolo-[3,4-c]pyridine derivative, in aqueous solutions.
Acta Pol Pharm. 2007 Jul-Aug;64(4):319-25.
4
Stability of ertapenem in aqueous solutions.
J Pharm Biomed Anal. 2007 Jan 17;43(2):445-9. doi: 10.1016/j.jpba.2006.07.021. Epub 2006 Aug 17.
5
Stability of ricobendazole in aqueous solutions.
J Pharm Biomed Anal. 2009 Jul 12;49(5):1282-6. doi: 10.1016/j.jpba.2009.02.032. Epub 2009 Mar 13.
6
Degradation kinetics of butylmethoxydibenzoylmethane (avobenzone) in aqueous solution.
Pharmazie. 2007 Oct;62(10):747-9.
7
Influence of formulation properties on chemical stability of captopril in aqueous preparations.
Pharmazie. 2008 Dec;63(12):872-7.
8
9
Stability of new potential ACE inhibitor in the aqueous solutions of different pH.
J Pharm Biomed Anal. 2009 Feb 20;49(2):295-303. doi: 10.1016/j.jpba.2008.11.029. Epub 2008 Nov 30.
10
Effects of hydroxypropyl-beta-cyclodextrin on the chemical stability of a naphthoquinone in aqueous solutions.
Pharmazie. 2003 Jan;58(1):32-7.
Zotero 插件