使用电化学产生的高价碘芳烃对酰胺进行对位氟化反应。
Para-Fluorination of Anilides Using Electrochemically Generated Hypervalent Iodoarenes.
作者信息
Berger Michael, Lenhard Marola S, Waldvogel Siegfried R
机构信息
Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.
出版信息
Chemistry. 2022 Jul 20;28(41):e202201029. doi: 10.1002/chem.202201029. Epub 2022 Jun 7.
Abstract
The para-selective fluorination reaction of anilides using electrochemically generated hypervalent ArIF is reported, with Et N ⋅ 5HF serving as fluoride source and as supporting electrolyte. This electrochemical reaction is characterized by a simple set-up, easy scalability and affords a broad variety of fluorinated anilides from easily accessible anilides in good yields up to 86 %.
摘要
报道了使用电化学产生的高价ArIF对酰苯胺进行对位选择性氟化反应，其中EtN·5HF用作氟源和支持电解质。该电化学反应具有装置简单、易于放大的特点，并且能以高达86%的良好产率从易于获得的酰苯胺制备出多种氟化酰苯胺。
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