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肺移植中循环死亡后的捐献。

Donation After Circulatory Death in lung transplantation.

机构信息

Department of Thoracic Surgery, University Hospitals Leuven, UZ Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium; Department of Chronic Diseases and Metabolism, KU Leuven University, Leuven, Belgium.

Department of Thoracic Surgery, University Hospitals Leuven, UZ Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium; Department of Chronic Diseases and Metabolism, KU Leuven University, Leuven, Belgium.

出版信息

Thorac Surg Clin. 2022 May;32(2):153-165. doi: 10.1016/j.thorsurg.2021.11.002.

Abstract

The continuing shortage of pulmonary grafts from donors after brain death has led to a resurgence of interest in lung transplantation from donors after circulatory death (DCD). Most lungs from donors after withdrawal from life-sustaining therapy can be recovered rapidly and transplanted directly without ex-vivo assessment in case functional warm ischemic time is limited to 30 to 60 min. The potential of the DCD lung pool is still underutilized and should be maximized in countries with existing legislation. Countries lacking a DCD pathway should be encouraged to develop national ethical, professional, and legal frameworks to address public and professional concerns.

摘要

脑死亡供体肺移植持续短缺,促使人们对循环死亡(DCD)供体肺移植重新产生兴趣。大多数在撤除生命支持治疗后供体的肺可以快速回收,并在功能热缺血时间限制在 30 至 60 分钟内的情况下直接进行移植,而无需进行体外评估。在已经有相关立法的国家,DCD 供肺池的潜力仍未得到充分利用,应该得到最大程度的利用。缺乏 DCD 途径的国家应鼓励制定国家伦理、专业和法律框架,以解决公众和专业人士的关切。

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