Li Jiaxi, Huang Pu, Xiong Jing, Liang Xinyue, Li Mei, Ke Hao, Chen Chunli, Han Yang, Huang Yanhong, Zhou Yan, Luo Ziqiang, Feng Dandan, Chen Chen
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Department of Health Management Center, Changsha Central Hospital, University of South China, Changsha, Hunan, China.
Endocr Connect. 2022 May 27;11(5):e220012. doi: 10.1530/EC-22-0012.
Ghrelin regulates body weight, food intake, and blood glucose. It also regulates insulin secretion from pancreatic islet cells. LEAP2 is a newly discovered endogenous ligand of the growth hormone secretagogue's receptor (GHSR). It not only antagonizes the stimulation of GHSR by ghrelin but also inhibits the constitutive activation of GHSR as an inverse agonist. Type 2 diabetes (T2D) patients have endocrine disorders with metabolic imbalance. Plasma levels of ghrelin and LEAP2 may be changed in obese and T2D patients. However, there is no report yet on circulating LEAP2 levels or ghrelin/LEAP2 ratio in T2D patients. In this study, fasting serum ghrelin and LEAP2 levels in healthy adults and T2D patients were assessed to clarify the association of two hormones with different clinical anthropometric and metabolic parameters.
A total of 16 females and 40 males, ages 23-68 years old normal (n = 27), and T2D patients (n = 29) were enrolled as a cross-sectional cohort.
Serum levels of ghrelin were lower but serum levels of LEAP2 were higher in T2D patients. Ghrelin levels were positively correlated with fasting serum insulin levels and HOMA-IR in healthy adults. LEAP2 levels were positively correlated with age and hemoglobin A1c (HbA1c) in all tested samples. Ghrelin/LEAP2 ratio was negatively correlated with age, fasting blood glucose, and HbA1c.
This study demonstrated a decrease in serum ghrelin levels and an increase in serum LEAP2 levels in T2D patients. LEAP2 levels were positively correlated with HbA1c, suggesting that LEAP2 was associated with T2D development. The ghrelin/LEAP2 ratio was closely associated with glycemic control in T2D patients showing a negative correlation with glucose and HbA1c.
胃饥饿素调节体重、食物摄入量和血糖。它还调节胰岛细胞的胰岛素分泌。LEAP2是一种新发现的生长激素促分泌素受体（GHSR）的内源性配体。它不仅拮抗胃饥饿素对GHSR的刺激，还作为反向激动剂抑制GHSR的组成性激活。2型糖尿病（T2D）患者存在内分泌紊乱和代谢失衡。肥胖和T2D患者的血浆胃饥饿素和LEAP2水平可能会发生变化。然而，关于T2D患者循环LEAP2水平或胃饥饿素/LEAP2比值尚无报道。在本研究中，评估了健康成年人和T2D患者的空腹血清胃饥饿素和LEAP2水平，以阐明这两种激素与不同临床人体测量和代谢参数之间的关联。
共有16名女性和40名男性，年龄在23 - 68岁之间，正常者（n = 27）和T2D患者（n = 29）被纳入横断面队列。
T2D患者的血清胃饥饿素水平较低，但血清LEAP2水平较高。在健康成年人中，胃饥饿素水平与空腹血清胰岛素水平和HOMA-IR呈正相关。在所有测试样本中，LEAP2水平与年龄和糖化血红蛋白（HbA1c）呈正相关。胃饥饿素/LEAP2比值与年龄、空腹血糖和HbA1c呈负相关。
本研究表明T2D患者血清胃饥饿素水平降低，血清LEAP2水平升高。LEAP2水平与HbA1c呈正相关，表明LEAP2与T2D的发生有关。胃饥饿素/LEAP2比值与T2D患者的血糖控制密切相关，与血糖和HbA1c呈负相关。
