基于微阵列的潜在 HSP90 抑制剂的筛选：从微生物中预测和分离。
Microarray-Based Screening of Putative HSP90 Inhibitors Predicted and Isolated from Microorganisms.
机构信息
Gottfried-Wilhelm-Leibniz University of Hannover, BMWZ (Zentrum für Biomolekulare Wirkstoffe), Hannover, Germany.
出版信息
Methods Mol Biol. 2022;2489:435-448. doi: 10.1007/978-1-0716-2273-5_22.
PMID:35524063
Abstract
Protein microarrays are useful tools for detecting the presence of a target where different prey and bait combinations exist. Here we describe the extended application for a functional target-oriented screening assay with full length Heat shock proteins (HSPs ) for the identification of novel compounds.
摘要
蛋白质微阵列是一种有用的工具，可用于检测存在不同猎物和诱饵组合的目标。在这里，我们描述了一种扩展的应用，用于针对全长热休克蛋白 (HSPs) 的功能性靶标筛选测定法，以鉴定新型化合物。
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