Louis-Sylvestre J
Diabete Metab. 1987 Feb;13(1):63-73.
Human studies had suggested that the cephalic phase of digestion induced a cephalic phase of insulin secretion. A detailed study of the intensity and time course of the phenomenon was performed in the free feeding rat and confirmed in other mammals. This secretion is reflexly triggered by food-related sensory stimuli and is vagally mediated. Anatomical, neurochemical electrophysiological and behavioural studies, showed that the reflex might be organized at the brain stem level receiving major modulation influences from the hypothalamus. The cephalic phase of insulin release is a conditioned reflex. One consequence of that early secretion is to damp down the important variations in the levels of circulating metabolites following absorption. The relationships between the amplitude of the cephalic phase insulin response and the basal insulin level on the one hand, the nutritional composition of the ingested food on the other, are still not clear. Some evidence exists that palatability, meal size and the amplitude of the cephalic phase insulin secretion are linked. This could be a possible etiology in some cases of nutritional obesity.
人体研究表明，消化的头期会引发胰岛素分泌的头期。在自由进食的大鼠中对该现象的强度和时程进行了详细研究，并在其他哺乳动物中得到了证实。这种分泌由与食物相关的感觉刺激反射性触发，并通过迷走神经介导。解剖学、神经化学、电生理学和行为学研究表明，该反射可能在脑干水平组织起来，并受到下丘脑的主要调节影响。胰岛素释放的头期是一种条件反射。这种早期分泌的一个结果是抑制吸收后循环代谢物水平的重要变化。头期胰岛素反应的幅度与基础胰岛素水平之间的关系，以及与摄入食物的营养成分之间的关系，目前仍不清楚。有证据表明，适口性、进餐量与头期胰岛素分泌的幅度有关。这可能是某些营养性肥胖病例的一个可能病因。
