Gu Xiaojing, Zhou Wei, Han Juan
Department of Biliary and Pancreatic Surgery, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Wuhan Polytechnic University, Wuhan, Hubei 430023, China.
Appl Bionics Biomech. 2022 Apr 29;2022:6106914. doi: 10.1155/2022/6106914. eCollection 2022.
Pancreatic cancer is one of the deadliest solid malignancies. Its surgical resection is technically very challenging and has a high risk of complications even after discharge. This study analyzed the risk factors associated with unplanned readmission after pancreatic cancer surgery.
Pancreatic cancer patients who were readmitted within 30 days after surgery were classified as the observation group, while those not readmitted within 30 days postsurgery were classified as the control group. The serum levels of gastrointestinal hormones, stress hormones, and peripheral immune cells of the two groups were compared at different intervals.
No significant differences in gender and age were observed between the two groups. At 7, 14, and 21 days postsurgery, the levels of gastrointestinal hormones motilin, gastrin, calcitonin gene-related peptide, and growth hormone-releasing peptide of the observation group were lower than the control group, while the levels of adrenocorticotropin, renin, angiotensin, and plasma aldosterone of the observation group were significantly higher than the control group. In addition, compared to the control group, lower levels of CD4+T cells, CD8+T cells, and NKT cells and higher levels of Treg, Breg, and MDSC cells were observed in the peripheral blood of the observation group.
The serum levels of gastrointestinal hormones, stress hormones, and peripheral immune cells could be associated with the risk of unplanned readmission within 30 days after pancreatic cancer surgery.
胰腺癌是最致命的实体恶性肿瘤之一。其手术切除在技术上极具挑战性，甚至在出院后并发症风险也很高。本研究分析了胰腺癌手术后非计划再入院的相关危险因素。
将术后30天内再次入院的胰腺癌患者分类为观察组，将术后30天内未再次入院的患者分类为对照组。比较两组在不同时间间隔的胃肠激素、应激激素和外周免疫细胞的血清水平。
两组在性别和年龄方面未观察到显著差异。术后7天、14天和21天，观察组的胃肠激素胃动素、胃泌素、降钙素基因相关肽和生长激素释放肽水平低于对照组，而观察组的促肾上腺皮质激素、肾素、血管紧张素和血浆醛固酮水平显著高于对照组。此外，与对照组相比，观察组外周血中CD4+T细胞、CD8+T细胞和NKT细胞水平较低，Treg、Breg和MDSC细胞水平较高。
胃肠激素、应激激素和外周免疫细胞的血清水平可能与胰腺癌手术后30天内非计划再入院的风险有关。
