Ishizaka K, Jardieu P, Akasaki M, Iwata M
Int Arch Allergy Appl Immunol. 1987;82(3-4):383-8. doi: 10.1159/000234233.
The IgE-potentiating and IgE-suppressive factors share a common structural gene and therefore a common polypeptide chain, and their biologic activities are decided by a post-translational glycosylation process. Under physiological conditions, this process is controlled by two T cell factors, i.e., the glycosylation-enhancing factor (GEF) and glycosylation-inhibiting factor (GIF). GIF is a fragment of phosphorylated lipocortin and has immunosuppressive effects. Repeated injections of this lymphokine into antigen-primed mice switched their T cells from the formation of IgE-potentiating factor to the formation of IgE-suppressive factor and facilitated the generation of antigen-specific suppressor T cells, which form antigen-specific GIF upon antigenic stimulation. The antigen-specific GIF suppressed the antibody response in a carrier-specific manner and has properties similar to antigen-specific suppressor T cell factors.
IgE增强因子和IgE抑制因子共享一个共同的结构基因，因此有一条共同的多肽链，它们的生物学活性由翻译后糖基化过程决定。在生理条件下，这个过程由两种T细胞因子控制，即糖基化增强因子（GEF）和糖基化抑制因子（GIF）。GIF是磷酸化脂皮质素的一个片段，具有免疫抑制作用。将这种淋巴因子反复注射到经抗原致敏的小鼠体内，可使它们的T细胞从产生IgE增强因子转变为产生IgE抑制因子，并促进抗原特异性抑制性T细胞的产生，后者在抗原刺激下形成抗原特异性GIF。抗原特异性GIF以载体特异性方式抑制抗体反应，其特性类似于抗原特异性抑制性T细胞因子。
