Department of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Târgu Mureș, 540142, Romania.
Laboratory of Antimicrobial Chemotherapy, Ion Ionescu de la Brad University of Life Sciences of Iași, Iași, 700490, Romania.
Future Microbiol. 2022 Jul;17:737-753. doi: 10.2217/fmb-2021-0296. Epub 2022 May 9.
Opportunistic infections with species are becoming more problematic, considering their increasing virulence and resistance to antifungal drugs. To assess the antifungal and anti-virulence activity of basil, cinnamon, clove, melaleuca, oregano and thyme essential oils (EOs) on five species (, , , and ). The MIC, growth rate, antibiofilm activity, regulation of gene expression (, , ) and germ-tube formation were evaluated by specific methods. Most EOs inhibited species growth and reduced the expression of some virulence factors. Cinnamon and clove EO showed the most significant inhibitory effects. The tested EOs are promising agents for facilitating the management of some infections.
考虑到物种的毒力和抗真菌药物的耐药性不断增加，与物种相关的机会性感染变得更加成问题。本研究评估了罗勒、肉桂、丁香、茶树、牛至和百里香精油（EOs）对五种物种（、、、和）的抗真菌和抗毒力活性。采用特定方法评估 MIC、生长率、抗生物膜活性、基因表达（、、）和产芽管的调节。大多数 EOs 抑制了物种的生长并降低了一些毒力因子的表达。肉桂和丁香 EO 显示出最显著的抑制作用。测试的 EOs 是促进管理某些感染的有前途的药物。
