Taufield P A, Druzin M L, Edersheim T E, Sealey J E, Laragh J H
J Hypertens Suppl. 1986 Dec;4(5):S96-8.
Plasma renin activity (PRA) was measured in the late third trimester in 26 hypertensive pregnant women and correlated with their infants' birth weights. Seven pre-eclamptics, six chronic hypertensives and 13 chronic hypertensives with superimposed pre-eclampsia were studied. Plasma renin activity was lower in 13 mothers with small for gestational age (SGA) infants (5.2 +/- 0.89 ng/ml per h, compared with 13 mothers with appropriate for gestational age (AGA) infants (16.65 +/- 2.37 ng/ml per h, P less than 0.001. The mean PRA was also lower in mothers with babies weighing less that 2500 g, regardless of gestational age, compared with 11 mothers with babies weighing more than 2500 g, (7.58 +/- 1.61 versus 15.86 +/- 2.73 ng/ml per h, P less than 0.050. Mean PRA was not significantly different in the different hypertensive groups, although women with chronic hypertension appeared to have lower PRA than pre-eclamptics. Our data suggest that in gestational hypertension, low PRA is associated with low infant birth weight, and that late third trimester PRA may therefore identify those at risk for poor fetal outcome.
对26例高血压孕妇在妊娠晚期测定了血浆肾素活性（PRA），并将其与她们婴儿的出生体重进行相关性分析。研究对象包括7例先兆子痫患者、6例慢性高血压患者和13例合并先兆子痫的慢性高血压患者。13例婴儿为小于胎龄儿（SGA）的母亲的血浆肾素活性较低（5.2±0.89 ng/ml每小时），与之相比，13例婴儿为适于胎龄儿（AGA）的母亲的血浆肾素活性为（16.65±2.37 ng/ml每小时），P＜0.001。无论胎龄如何，婴儿体重小于2500 g的母亲的平均PRA也较低，与之相比，11例婴儿体重大于2500 g的母亲的平均PRA为（7.58±1.61与15.86±2.73 ng/ml每小时），P＜0.050。不同高血压组之间的平均PRA无显著差异，尽管慢性高血压患者的PRA似乎低于先兆子痫患者。我们的数据表明，在妊娠高血压中，低PRA与低婴儿出生体重相关，因此妊娠晚期PRA可能有助于识别胎儿结局不良的风险人群。
