• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

载姜黄素声敏靶向递药系统联合超声破坏微泡治疗恶性脑胶质瘤的实验研究

A Gambogic Acid-Loaded Delivery System Mediated by Ultrasound-Targeted Microbubble Destruction: A Promising Therapy Method for Malignant Cerebral Glioma.

机构信息

Henan Key Laboratory of Medical Tissue Regeneration, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, 453003, People's Republic of China.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, 453003, People's Republic of China.

出版信息

Int J Nanomedicine. 2022 May 3;17:2001-2017. doi: 10.2147/IJN.S344940. eCollection 2022.

DOI:10.2147/IJN.S344940
PMID:35535034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9078874/
Abstract

BACKGROUND

The blood-brain barrier (BBB) inhibits the delivery of macromolecular chemotherapeutic drugs to brain tumors, leading to low utilization rates and toxic side effects to surrounding tissues and organs. Ultrasonic targeted microbubble destruction (UTMD) technology can open the BBB, leading to a new type of drug delivery system with particular utility in glioma.

PURPOSE

We have developed a new type of drug-loaded microbubble complex based on poly(lactic-co-glycolic acid) (PLGA) that targets gambogic acid (GA) to the area of brain tumors through UTMD.

METHODS

GA/PLGA nanoparticles were prepared by the double emulsification method, and cationic microbubbles (CMBs) were prepared by a thin film hydration method. The GA/PLGA-CMB microbubble complex was assembled through electrostatic attractions and was characterized chemically. The anti-glioblastoma effect of GA/PLGA-CMB combined with focused ultrasound (FUS) was evaluated by biochemical and imaging assays in cultured cells and model mice.

RESULTS

GA/PLGA-CMB combined with FUS demonstrated a significant inhibitory effect on glioblastoma cell lines U87 and U251 as compared with controls (P<0.05). Tumor access and imaging analyses demonstrated that administration of GA/PLGA-CMBs combined with FUS can open the BBB and target the treatment of glioblastoma in a mouse model, as compared with control groups (P<0.05).

CONCLUSION

The combination of PLGA-CMB with FUS provides an effective and biocompatible drug delivery system, and its application to the delivery of GA in a mouse glioblastoma model was successful.

摘要

背景

血脑屏障（BBB）抑制了大分子化学治疗药物向脑肿瘤的输送，导致其在脑肿瘤中的利用率低，并对周围组织和器官产生毒性副作用。超声靶向微泡破坏（UTMD）技术可以打开血脑屏障，为胶质瘤开辟了一种新型的药物输送系统。

目的

我们开发了一种基于聚乳酸-羟基乙酸共聚物（PLGA）的新型载药微泡复合物，通过 UTMD 将藤黄酸（GA）靶向递送至脑肿瘤区域。

方法

采用复乳法制备 GA/PLGA 纳米粒，薄膜水化法制备阳离子微泡（CMBs）。通过静电吸引组装 GA/PLGA-CMB 微泡复合物，并进行化学表征。通过生化和成像检测，在培养的细胞和模型小鼠中评估 GA/PLGA-CMB 联合聚焦超声（FUS）对胶质母细胞瘤的治疗效果。

结果

与对照组相比，GA/PLGA-CMB 联合 FUS 对 U87 和 U251 胶质母细胞瘤细胞系表现出显著的抑制作用（P<0.05）。肿瘤通透性和成像分析表明，与对照组相比，GA/PLGA-CMB 联合 FUS 给药可打开血脑屏障，靶向治疗小鼠模型中的胶质母细胞瘤（P<0.05）。

结论

PLGA-CMB 联合 FUS 提供了一种有效且生物相容的药物输送系统，成功应用于 GA 在小鼠脑胶质瘤模型中的递送。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/bba2ec3b6e6b/IJN-17-2001-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/414bdd031852/IJN-17-2001-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/584079953ab8/IJN-17-2001-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/03524846479c/IJN-17-2001-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/6bb74b0cba97/IJN-17-2001-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/b4735a69f162/IJN-17-2001-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/46cbd04d83fe/IJN-17-2001-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/1557a48d3f58/IJN-17-2001-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/a616e810c592/IJN-17-2001-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/50e158e3d221/IJN-17-2001-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/e43cf490ac00/IJN-17-2001-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/4acd10ff02a2/IJN-17-2001-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/bba2ec3b6e6b/IJN-17-2001-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/414bdd031852/IJN-17-2001-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/584079953ab8/IJN-17-2001-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/03524846479c/IJN-17-2001-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/6bb74b0cba97/IJN-17-2001-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/b4735a69f162/IJN-17-2001-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/46cbd04d83fe/IJN-17-2001-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/1557a48d3f58/IJN-17-2001-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/a616e810c592/IJN-17-2001-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/50e158e3d221/IJN-17-2001-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/e43cf490ac00/IJN-17-2001-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/4acd10ff02a2/IJN-17-2001-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/9078874/bba2ec3b6e6b/IJN-17-2001-g0012.jpg

相似文献

1
A Gambogic Acid-Loaded Delivery System Mediated by Ultrasound-Targeted Microbubble Destruction: A Promising Therapy Method for Malignant Cerebral Glioma.载姜黄素声敏靶向递药系统联合超声破坏微泡治疗恶性脑胶质瘤的实验研究
Int J Nanomedicine. 2022 May 3;17:2001-2017. doi: 10.2147/IJN.S344940. eCollection 2022.
2
Ultrasound-triggered drug delivery for glioma therapy through gambogic acid-loaded nanobubble-microbubble complexes.超声触发载藤黄酸纳米泡-微泡复合物用于脑胶质瘤治疗的递药系统
Biomed Pharmacother. 2022 Jun;150:113042. doi: 10.1016/j.biopha.2022.113042. Epub 2022 May 2.
3
Effect of Gambogic Acid-Loaded Porous-Lipid/PLGA Microbubbles in Combination With Ultrasound-Triggered Microbubble Destruction on Human Glioma.载有藤黄酸的多孔脂质/聚乳酸-羟基乙酸共聚物微泡联合超声触发微泡破坏对人胶质瘤的影响
Front Bioeng Biotechnol. 2021 Sep 15;9:711787. doi: 10.3389/fbioe.2021.711787. eCollection 2021.
4
Focused Ultrasound-Mediated Blood-Brain Barrier Opening Increases Delivery and Efficacy of Etoposide for Glioblastoma Treatment.聚焦超声介导的血脑屏障开放增加依托泊苷治疗脑胶质母细胞瘤的递送和疗效。
Int J Radiat Oncol Biol Phys. 2021 Jun 1;110(2):539-550. doi: 10.1016/j.ijrobp.2020.12.019. Epub 2020 Dec 17.
5
Brain tumor-targeted delivery and therapy by focused ultrasound introduced doxorubicin-loaded cationic liposomes.通过聚焦超声将载多柔比星的阳离子脂质体递送至脑肿瘤并进行治疗。
Cancer Chemother Pharmacol. 2016 Feb;77(2):269-80. doi: 10.1007/s00280-015-2926-1. Epub 2015 Dec 14.
6
Enhanced delivery of paclitaxel liposomes using focused ultrasound with microbubbles for treating nude mice bearing intracranial glioblastoma xenografts.使用聚焦超声联合微泡增强紫杉醇脂质体递送用于治疗荷颅内胶质母细胞瘤异种移植瘤的裸鼠。
Int J Nanomedicine. 2017 Aug 9;12:5613-5629. doi: 10.2147/IJN.S136401. eCollection 2017.
7
Delivery of DNA octahedra enhanced by focused ultrasound with microbubbles for glioma therapy.超声微泡造影剂聚焦破坏递送 DNA 八面体用于脑胶质瘤治疗
J Control Release. 2022 Oct;350:158-174. doi: 10.1016/j.jconrel.2022.08.019. Epub 2022 Aug 18.
8
Closed-loop control of targeted ultrasound drug delivery across the blood-brain/tumor barriers in a rat glioma model.在大鼠脑胶质瘤模型中，经血脑/肿瘤屏障靶向超声药物输送的闭环控制。
Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10281-E10290. doi: 10.1073/pnas.1713328114. Epub 2017 Nov 13.
9
Glioma-targeted therapy using Cilengitide nanoparticles combined with UTMD enhanced delivery.使用西仑吉肽纳米颗粒联合超声靶向微泡破坏技术增强递送的胶质瘤靶向治疗。
J Control Release. 2016 Feb 28;224:112-125. doi: 10.1016/j.jconrel.2016.01.015. Epub 2016 Jan 11.
10
A review of potential applications of MR-guided focused ultrasound for targeting brain tumor therapy.MR 引导聚焦超声在脑肿瘤治疗靶向中的潜在应用综述。
Neurosurg Focus. 2018 Feb;44(2):E10. doi: 10.3171/2017.11.FOCUS17620.

引用本文的文献

1
Navigating Glioma Complexity: The Role of Abnormal Signaling Pathways in Shaping Future Therapies.应对神经胶质瘤的复杂性：异常信号通路在塑造未来治疗方法中的作用。
Biomedicines. 2025 Mar 20;13(3):759. doi: 10.3390/biomedicines13030759.
2
Overcoming challenges in glioblastoma treatment: targeting infiltrating cancer cells and harnessing the tumor microenvironment.克服胶质母细胞瘤治疗中的挑战：靶向浸润癌细胞并利用肿瘤微环境。
Front Cell Neurosci. 2023 Dec 21;17:1327621. doi: 10.3389/fncel.2023.1327621. eCollection 2023.
3
Exploring the Theranostic Applications and Prospects of Nanobubbles.

本文引用的文献

1
Effect of Gambogic Acid-Loaded Porous-Lipid/PLGA Microbubbles in Combination With Ultrasound-Triggered Microbubble Destruction on Human Glioma.载有藤黄酸的多孔脂质/聚乳酸-羟基乙酸共聚物微泡联合超声触发微泡破坏对人胶质瘤的影响
Front Bioeng Biotechnol. 2021 Sep 15;9:711787. doi: 10.3389/fbioe.2021.711787. eCollection 2021.
2
UTMD promoted local delivery of miR-34a-mimic for ovarian cancer therapy.UTMD 促进了 miR-34a 模拟物在卵巢癌治疗中的局部递送。
Drug Deliv. 2021 Dec;28(1):1616-1625. doi: 10.1080/10717544.2021.1955041.
3
Cavitation effect in two-dimensional ultrasonic rolling process.
探索纳米气泡的治疗应用和前景。
Curr Pharm Biotechnol. 2024;25(9):1167-1181. doi: 10.2174/0113892010248189231010085827.
4
Microbubble Delivery Platform for Ultrasound-Mediated Therapy in Brain Cancers.用于脑癌超声介导治疗的微泡递送平台
Pharmaceutics. 2023 Feb 19;15(2):698. doi: 10.3390/pharmaceutics15020698.
二维超声滚压过程中的空化效应。
Ultrasonics. 2021 Aug;115:106456. doi: 10.1016/j.ultras.2021.106456. Epub 2021 Apr 25.
4
Frontiers in the treatment of glioblastoma: Past, present and emerging.胶质母细胞瘤治疗的前沿：过去、现在和未来。
Adv Drug Deliv Rev. 2021 Apr;171:108-138. doi: 10.1016/j.addr.2021.01.012. Epub 2021 Jan 21.
5
Ultrasound-Mediated Oxygen Delivery for Enhanced Radiotherapy with Ultrasound Imaging Guidance.超声介导氧输送增强放疗的超声成像引导。
J Biomed Nanotechnol. 2020 Nov 1;16(11):1633-1643. doi: 10.1166/jbn.2020.2990.
6
The effect of ultrasound cavitation on endothelial cells.超声空化对血管内皮细胞的影响。
Exp Biol Med (Maywood). 2021 Apr;246(7):758-770. doi: 10.1177/1535370220982301. Epub 2021 Jan 18.
7
Gambogic Acid as a Candidate for Cancer Therapy: A Review.藤黄酸作为癌症治疗的候选药物：综述。
Int J Nanomedicine. 2020 Dec 22;15:10385-10399. doi: 10.2147/IJN.S277645. eCollection 2020.
8
Pulmonary cavitation in patients with thyroid cancer receiving antiangiogenic agents.甲状腺癌患者接受抗血管生成药物治疗后的肺部空洞。
BMC Cancer. 2020 Dec 2;20(1):1181. doi: 10.1186/s12885-020-07693-5.
9
Gambogic acid ameliorates high glucose- and palmitic acid-induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo.藤黄酸通过激活Nrf2信号通路减轻高糖和棕榈酸诱导的ARPE-19细胞炎症反应：体外实验
Cell Stress Chaperones. 2021 Mar;26(2):367-375. doi: 10.1007/s12192-020-01182-1. Epub 2020 Nov 27.
10
Targeted galectin-7 inhibition with ultrasound microbubble targeted gene therapy as a sole therapy to prevent acute rejection following heart transplantation in a Rodent model.在啮齿动物模型中，采用超声微泡靶向基因疗法对半乳糖凝集素-7进行靶向抑制，作为预防心脏移植后急性排斥反应的单一疗法。
Biomaterials. 2020 Dec;263:120366. doi: 10.1016/j.biomaterials.2020.120366. Epub 2020 Sep 6.